{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:27:58Z","timestamp":1791329278204,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Hereditary hemorrhagic telangiectasia (HHT) is a hereditary condition that is associated with arteriovenous malformations. A common site for these malformations is the nasal mucosa, which is associated with severe epistaxis and debilitation for affected patients. We evaluated the efficacy and safety of blue light laser technology in treating these endonasal manifestations in a retrospective chart analysis. Additionally, we compared blue light laser technology to bipolar coagulation in an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>We performed a retrospective chart analysis of all patients that were diagnosed with HHT and received endonasal blue light laser treatment between 10\/2017 and 04\/2019. In addition, we performed bipolar or blue light laser coagulation of all macroscopically visible vessels on thyroid gland lobes (<jats:italic>n<\/jats:italic>\u2009=\u20094) from Dunkin\u2013Hartley Guinea Pigs. Hematoxylin\u2010eosin (HE) staining was then used to visualize depth and area of coagulation surrounding these vessels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fifty\u2010one treatments in 23 patients were analyzed. Under regular blue light laser treatment, quality of life (QOL), indicated on a visual analog scale from 1 to 10, gradually increased significantly from 5.6\u2009\u00b1\u20090.5 (before the first treatment) to 7.5\u2009\u00b1\u20090.9 (after the second treatment). Following this, QOL remained steady throughout additional treatments. Adverse effects were not recorded. HE staining showed that coagulation depth (162\u2009\u00b1\u200956 vs. 586\u2009\u00b1\u2009192\u2009\u00b5m) and area (74\u2009\u00b1\u200935 vs. 1015\u2009\u00b1\u2009449\u2009\u00b5m<jats:sup>2<\/jats:sup>) were significantly lower after laser treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Blue light laser therapy is safe and efficient in treating HHT. Damage to the surrounding tissue is significantly lower compared with bipolar coagulation. \u00a9 2020 The Authors. <jats:italic>Lasers in Surgery and Medicine<\/jats:italic> published by Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23289","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T07:16:54Z","timestamp":1592896614000},"page":"309-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Safety and Efficacy of Blue Light Laser Treatment in Hereditary Hemorrhagic Telangiectasia"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-5899","authenticated-orcid":false,"given":"Mattis","family":"Bertlich","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Munich Marchioninistr. 15 Munich 81377 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Kashani","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Munich Marchioninistr. 15 Munich 81377 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard G.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Munich Marchioninistr. 15 Munich 81377 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wiebringhaus","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Munich Marchioninistr. 15 Munich 81377 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Ihler","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Munich Marchioninistr. 15 Munich 81377 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Freytag","sequence":"additional","affiliation":[{"name":"Epigenetics and Genomics The Harry Perkins Institute of Medical Research 6 Verdun St Nedlands Western Australia 6009 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gires","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Munich Marchioninistr. 15 Munich 81377 Germany"},{"name":"Clinical Cooperation Group \u201cPersonalized Radiotherapy in Head and Neck Cancer\u201d Helmholtz Zentrum Marchioninistr. 25 Munich 81377 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"K\u00fchnel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Regensburg Franz\u2010Josef\u2010Strau\u00df\u2010Allee 11 Regensburg 93047 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Haubner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Munich Marchioninistr. 15 Munich 81377 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