{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:44:36Z","timestamp":1789141476815,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To compare the efficacy of autologous platelet\u2010rich plasma (PRP), ablative fractional carbon dioxide (FCO<jats:sub>2<\/jats:sub>) laser, and their combination in the treatment of atrophic acne scars, both clinically and immuno\u2010histopathologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Sixty patients were randomly divided into three equal groups. Group 1 received intradermal PRP injection sessions. Group 2 received FCO<jats:sub>2<\/jats:sub> laser sessions. Group 3 received FCO<jats:sub>2<\/jats:sub> laser followed by intradermal PRP injection sessions. Each group received three sessions at monthly intervals. The final assessment took place 3 months after the last session. Skin biopsies were obtained before and 1 month after treatment sessions with pathological evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combined PRP and FCO<jats:sub>2<\/jats:sub> laser\u2010treated patients had a better clinical response, fewer side effects, and shorter downtime than FCO<jats:sub>2<\/jats:sub> laser alone. PRP\u2010treated patients had some improvement but significantly lower than the other two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current study concluded that a combination of PRP and FCO<jats:sub>2<\/jats:sub> laser is an effective and safe modality in the treatment of atrophic acne scars with better results than PRP or FCO<jats:sub>2<\/jats:sub> laser alone. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23306","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T13:30:51Z","timestamp":1596893451000},"page":"458-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Ablative Fractional Carbon Dioxide Laser and Autologous Platelet\u2010Rich Plasma in the Treatment of Atrophic Acne Scars: A Comparative Clinico\u2010Immuno\u2010Histopathological Study"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-1639","authenticated-orcid":false,"given":"Esraa E.","family":"El\u2010Hawary","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Andrology, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Andrology, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer A.","family":"Hodeib","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Andrology, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Shareef","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Andrology, Faculty of Medicine Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.47"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113451"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.150742"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23218"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02280.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.01.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23201"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12160"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32354.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12392"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02009.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1455"},{"key":"e_1_2_6_14_1","unstructured":"ImageJ. 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