{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:05:17Z","timestamp":1788998717163,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Treatment of melasma with lasers remains a challenge due to its limited clinical efficacy in addition to high rates of recurrence and side effects. Recently, picosecond lasers have shown favorable results in treatment of benign pigmented lesions. To compare the efficacy and safety of using a 755\u2010nm picosecond laser for the treatment of melasma in a split\u2010face manner, having one side treated with a fractionated beam (diffractive lens array [DLA] coupling) and with a full\u2010beam (flat optics) on the other side.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design\/Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Eighteen subjects presenting with mixed\u2010type melasma were enrolled. Each patient was randomly treated with a 755\u2010nm picosecond laser coupled with DLA on one side of the face and without DLA (flat optics) on the other side. The laser was delivered through an 8\u2010mm spot size with an average fluence of 0.4\u2009J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      at 2.5\u2009Hz for a total of two passes without pulse overlapping. All subjects received five monthly treatments. Subjective (clinical evaluation) and objective (color readings) assessments on the degree of pigment clearance and adverse effects were obtained at 1\u2010, 3\u2010, and 6\u2010month after the final treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 6 months after the last treatment, physician\u2010rating scores were 1.50\u2009\u00b1\u20090.76 and 1.50\u2009\u00b1\u20090.65 of the DLA and flat\u2010optics sides, respectively. Pigment clearance significantly improved from 1 to 6 months after the treatment on each side (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.019 on DLA and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.023 on flat\u2010optics sides). No statistically significant differences in physician\u2010rating scores between the two treatment techniques were observed at all follow\u2010up visits. Objective assessments of melasma clearance corresponded to the clinical evaluation. However, the full\u2010beam (flat optics) provided lower incidence of pos\u2010tinflammatory hyperpigmentation than the fractioned one.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A 755\u2010nm picosecond laser is safe and effective for the treatment of melasma in dark\u2010skinned individuals. The use of DLA does not provide additional benefit over the flat optics in clearing pigmentation. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals LLC<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.23312","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T09:33:58Z","timestamp":1598866438000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["A Prospective, Split\u2010Face, Randomized Study Comparing a 755\u2010nm Picosecond Laser With and Without Diffractive Lens Array in the Treatment of Melasma in Asians"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-7963","authenticated-orcid":false,"given":"Woraphong","family":"Manuskiatti","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadakan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ploypailin","family":"Tantrapornpong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn Anne G.","family":"Cembrano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanya","family":"Techapichetvanich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3926-2193","authenticated-orcid":false,"given":"Rungsima","family":"Wanitphakdeedecha","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok 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