{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:14:43Z","timestamp":1790727283046,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307906\u20107"],"award-info":[{"award-number":["307906\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To investigate pro\u2010 and anti\u2010inflammatory cytokines and nitrite salivary levels in patients with head and neck cancer receiving photobiomodulation therapy (PBMT) associated with a Preventive Oral Care Program (POCP), for prevention and control of oral mucositis (OM) during radiotherapy (RT) associated or not with chemotherapy protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>In this randomized double\u2010blinded clinical trial, 48 patients were randomly assigned to two groups: PBMT (<jats:italic>n<\/jats:italic>\u2009=\u200925) and Control (<jats:italic>n<\/jats:italic>\u2009=\u200923). In the PBMT group, patients were submitted to PBMT associated with the POCP. In the Control group, patients were submitted only to the POCP. Saliva samples were collected in the 1st (baseline), 7th, 14th, 21st, and 30th sessions of RT, and the levels of interleukin\u20106 (IL\u20106), IL\u20108, IL\u201010, IL\u201012p70, IL\u20101\u03b2, and tumoral necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) were measured using the cytometric bead array. Nitrite levels were measured by colorimetric method. OM was assessed using the World Health Organization and the National Cancer Institute scales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the PBMT group presented less severe OM. PBMT tended to stabilize nitrite concentration levels during the RT regimen. The IL\u20101\u03b2 concentration was associated with higher OM scores. PBMT promoted an increase in IL\u201012p70, TNF\u2010\u03b1, and IL\u201010 concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PBMT was effective in the prevention and control of severe OM, and its mechanism of action may be related to a better balance of inflammatory response that may favor injury control. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23328","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T19:59:08Z","timestamp":1601495948000},"page":"671-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Effect of Photobiomodulation on Nitrite and Inflammatory Activity in Radiotherapy\u2010Induced Oral Mucositis: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4729-6916","authenticated-orcid":false,"given":"Allisson F. L.","family":"Martins","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Patologia Oral da, Faculdade de Odontologia da Universidade Federal de Goi\u00e1s Avenida Universit\u00e1ria Esquina com 1\u00aa Avenida, s\/n. Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"},{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0498-4778","authenticated-orcid":false,"given":"Mar\u00edlia O.","family":"Morais","sequence":"additional","affiliation":[{"name":"Setor de Odontologia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206\u2014Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"},{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-8723","authenticated-orcid":false,"given":"Sebasti\u00e3o S.","family":"Sousa\u2010Neto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia Oral da, Faculdade de Odontologia da Universidade Federal de Goi\u00e1s Avenida Universit\u00e1ria Esquina com 1\u00aa Avenida, s\/n. Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"},{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica F.","family":"Oton\u2010Leite","sequence":"additional","affiliation":[{"name":"Setor de Odontologia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206\u2014Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"},{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-6163","authenticated-orcid":false,"given":"Carlos H.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Patologia Oral da, Faculdade de Odontologia da Universidade Federal de Goi\u00e1s Avenida Universit\u00e1ria Esquina com 1\u00aa Avenida, s\/n. Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"},{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-1325","authenticated-orcid":false,"given":"Marize C.","family":"Valadares","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Farmacologia e Toxicologia Celular da, Faculdade de Farm\u00e1cia da Universidade Federal de Goi\u00e1s 5\u00aa Avenida Esquina com Rua 240, s\/n. Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74605\u2010170 Brazil"},{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9445-8674","authenticated-orcid":false,"given":"Nilceana M. A.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"},{"name":"Laborat\u00f3rio de Patologia Oral da, Faculdade de Odontologia da Universidade Federal de Goi\u00e1s Avenida Universit\u00e1ria Esquina com 1\u00aa Avenida, s\/n. Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2117-5593","authenticated-orcid":false,"given":"Aline C.","family":"Batista","sequence":"additional","affiliation":[{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"},{"name":"Departamento de Preven\u00e7\u00e3o e Reabilita\u00e7\u00e3o Oral da, Faculdade de Odontologia da Universidade Federal de Goi\u00e1s Avenida Universit\u00e1ria Esquina com 1\u00aa Avenida, s\/n. Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-4849","authenticated-orcid":false,"given":"Cl\u00e1udio R.","family":"Leles","sequence":"additional","affiliation":[{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"},{"name":"Laborat\u00f3rio de Patologia Oral da, Faculdade de Odontologia da Universidade Federal de Goi\u00e1s Avenida Universit\u00e1ria Esquina com 1\u00aa Avenida, s\/n. Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-3279","authenticated-orcid":false,"given":"Elismauro F.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Departamento de Radioterapia do Hospital de C\u00e2ncer Ara\u00fajo Jorge. R. 239, 206 Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74175\u2010120 Brazil"},{"name":"Laborat\u00f3rio de Patologia Oral da, Faculdade de Odontologia da Universidade Federal de Goi\u00e1s Avenida Universit\u00e1ria Esquina com 1\u00aa Avenida, s\/n. Setor Universit\u00e1rio Goi\u00e2nia Goi\u00e1s 74605\u2010220 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70580-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572011000500003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20162"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.08.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e3283462086"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/936486"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02801-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.12-RE-01"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1605-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04890-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2012.00303.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21737"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1684-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.08.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2050"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1376097"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107418"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02722-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0603-9"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20920"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.12.125008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1624-2"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22349"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12230"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064918"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357900600814698"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2263-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7010.1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20143714"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121851"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.11.028"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2014.50.2.58"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-1181-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12151"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12255"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22487"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0955-5"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4343"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3196-8"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-015-2956-6"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05283-1"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(97)00065-1"},{"key":"e_1_2_8_44_1","unstructured":"National Cancer Institute (NCI) National Cancer Health (NIH) Common Toxicity Criteria (CTCAE). Version 5.0 Nov 2017.https:\/\/ctep.cancer.gov. Accessed 25 January 2019."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04893-z"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3783-8"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-64"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-16"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03261.x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24525"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04838-6"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000053"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217753842"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05084-6"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.055"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.223891"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH754>3.0.CO;2-P"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05041-3"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4046-z"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.04.004"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.05.018"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2008-0024"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2016.017863"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4579279"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.08.021"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.03.009"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21149"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.08.008"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23328","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:28:56Z","timestamp":1693416536000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/lsm.23328"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23328","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"assertion":[{"value":"2020-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}