{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:29:46Z","timestamp":1782318586399,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Melasma may be related to aberrant blood vessels, but there has been no report on\u00a0the utility of dynamic optical coherence tomography (D\u2010OCT) in\u00a0studying\u00a0vessel characteristics in melasma. We studied the characteristics of cutaneous blood vessels in melasma and the effects of oral tranexamic acid (TXA) with D\u2010OCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Six patients with moderate to severe melasma had a\u00a0D\u2010OCT scanning of the areas on the face affected by melasma and not affected by it. Three of them had scans within 3 months after starting oral TXA and at a follow\u2010up visit. Blood flow at different depths of the skin and vessel diameter were compared between the melasma and normal skin. For those taking oral TXA, we compared the percent change of blood flow and diameter between the melasma and normal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dermal blood flow and vessel diameter were greater in the melasma skin than in the normal skin. Oral TXA reduced dermal blood flow in both the melasma and normal skin, but the reduction was more dramatic in the lesional melasma skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>D\u2010OCT findings that (i) dermal blood vessels in melasma are increased in size and flow and (ii) oral TXA reduced the vessel size and flow, providing\u00a0evidence supporting the relationship between melasma and cutaneous blood vessels. D\u2010OCT may be utilized in measuring response to treatments targeting melasma. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23345","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T18:36:46Z","timestamp":1604860606000},"page":"861-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dynamic Optical Coherence Tomography of Cutaneous Blood Vessels in Melasma and Vessel Response to Oral Tranexamic Acid"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5977-8587","authenticated-orcid":false,"given":"Hyemin","family":"Pomerantz","sequence":"first","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitalee P.","family":"Christman","sequence":"additional","affiliation":[{"name":"SkinCare Physicians  Chestnut Hill Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley S.","family":"Bloom","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York  New York New York"},{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2668-7237","authenticated-orcid":false,"given":"Margo","family":"Lederhandler","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York  New York New York"},{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Connecticut Health Center  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Holmes","sequence":"additional","affiliation":[{"name":"Michelson Diagnostics Ltd.  Kent UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy G.","family":"Geronemus","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York  New York New York"},{"name":"The Ronald O. Perelman Department of Dermatology New York University School of Medicine  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22816"},{"key":"e_1_2_4_3_1","first-page":"e23008","article-title":"Acne vulgaris severity graded by in vivo reflectance confocal microscopy and optical coherence tomography","volume":"2","author":"Fuchs CSK","year":"2018","journal-title":"Lasers Surg Med"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.4.040901"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-015-0005-8"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14508"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.1006"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.01.009"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00345.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01564.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(98)00212-7"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32133.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-013-1498-8"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.01057.x"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T04:38:48Z","timestamp":1693283928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,8]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/lsm.23345"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23345","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,8]]},"assertion":[{"value":"2020-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}