{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:24:18Z","timestamp":1777289058702,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["The Asia Research Center Fund"],"award-info":[{"award-number":["The Asia Research Center Fund"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Skin barrier is often compromised following ablative fractional carbon dioxide laser (AFCO<jats:sub>2<\/jats:sub>) therapy for acne scarring. The resultant downtime, even of a few days' duration, can be of significant concern to patients. We evaluated the efficacy and safety of topical 0.5% timolol maleate (TM) for its role in short\u2010term restoration of the skin's biophysical properties after laser treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>This double\u2010blind, placebo\u2010controlled trial included participants aged 18\u201350 years with atrophic acne scars for at least 3 months. After undergoing laser therapy, they applied 0.5% TM to one cheek and normal saline to the contralateral cheek (control) for 7 days. Corneometry, transepidermal water loss (TEWL) measurement, colorimetry, and clinical outcome parameters (erythema, edema, crusting, pruritus, and tightness scores) were evaluated at baseline and 48, 96, and 168\u2009hours after AFCO<jats:sub>2<\/jats:sub> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five healthy participants completed the study. Most participants had Fitzpatrick skin phototype IV. The TM\u2010treated side showed statistically higher corneometry values and lower TEWL than the control side at every follow\u2010up visit (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The crusting score at 96\u2009hours post\u2010AFCO<jats:sub>2<\/jats:sub> treatment was also significantly better on the TM side. No adverse events occurred during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Application of topical 0.5% TM twice daily improves the skin\u2010barrier function and might promote re\u2010epithelialization after laser procedures. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23354","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T05:32:17Z","timestamp":1605850337000},"page":"610-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Topical 0.5% Timolol Maleate Significantly Enhances Skin\u2010Barrier Restoration After Fractional Carbon Dioxide Laser Treatment for Acne Scars"],"prefix":"10.1002","volume":"53","author":[{"given":"Kometh","family":"Kimwattananukul","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Division of Dermatology, Department of Medicine King Chulalongkorn Memorial Hospital  The Thai Red Cross Society Bangkok 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