{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:27:40Z","timestamp":1776356860485,"version":"3.51.2"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Fractional 1064\u2010nm picosecond\u2010domain laser has recently been utilized for the treatment of atrophic acne scars and showed promising results. However, data on the safety and efficacy of this procedure in dark\u2010skinned patients are limited. This prospective, self\u2010controlled study was conducted to objectively evaluate the safety and efficacy of a 1064\u2010nm picosecond laser coupled with a microlens array (MLA) for the treatment of atrophic acne scars on Asian skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Twenty\u2010six subjects of Fitzpatrick skin types (FSTs) III and IV with atrophic acne scars were enrolled. All subjects were treated with a 1064\u2010nm picosecond laser (spot size of 8\u2009mm, fluence of 1.0\u2009J\/cm<jats:sup>2<\/jats:sup>, a repetition rate of 10\u2009Hz) in combination with the MLA handpiece for an average of three passes, for 6 monthly sessions. Objective (measurement of scar volume using three\u2010dimensional (3D) photography and skin roughness analysis using ultraviolet A\u2010light video camera) and subjective (clinical evaluation by two blinded dermatologists) assessments were obtained at baseline and at 1, 3, and 6 months after the final treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant reduction of the scar volume from baseline at 1, 3, and 6 months after the final treatment were observed by 3D photography and ultraviolet A\u2010light video camera. At the 6\u2010month follow\u2010up, 50% (13 of 26) of the subjects were rated as having at least 50% improvement of the scars. The rate of improvement significantly increased from the 1\u2010month follow\u2010up to the 6\u2010month follow\u2010up (<jats:italic>P<\/jats:italic>\u2009=\u20090.013). Similarly, at the 6\u2010month follow\u2010up, the scar volume (<jats:italic>P<\/jats:italic>\u2009=\u20090.024) and skin roughness (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) also significantly improved, in comparison with the baseline. Mild postinflammatory hyperpigmentation (PIH) was observed to develop in approximately 18% of all the treatment sessions. All cases of PIH were temporary and resolved within 4 weeks on average.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 1064\u2010nm picosecond laser with MLA is a safe therapeutic alternative for the treatment of atrophic acne scars in dark\u2010skinned individuals. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23368","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T01:45:27Z","timestamp":1608255927000},"page":"899-905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Objective and Long\u2010Term Evaluation of the Efficacy and Safety of a 1064\u2010nm Picosecond Laser With Fractionated Microlens Array for the Treatment of Atrophic Acne Scar in Asians"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-7963","authenticated-orcid":false,"given":"Woraphong","family":"Manuskiatti","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 10700 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