{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:28:51Z","timestamp":1790659731644,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571902"],"award-info":[{"award-number":["81571902"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Both fractional micro\u2010plasma radiofrequency (RF) and fractional microneedle RF are novel devices that can be applied for the treatment of atrophic acne scars, and they have both been proved to be effective. To compare the clinical effectiveness and adverse reactions of fractional micro\u2010plasma RF and fractional microneedle RF for the therapy of facial atrophic acne scars in a randomized split\u2010face study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Sixty patients with facial atrophic acne scars received three applications at 2\u2010month intervals in a randomized split\u2010face study using fractional micro\u2010plasma RF and fractional microneedle RF on different sides of the face. Three independent dermatologists evaluated the improvement in acne scars using the ECCA grading scale (Echelle d'Evaluation Clinique des Cicatrices d'Acn\u00e9) by comparing the digital images and graded the improvement in the acne scars. Patients were asked to provide a self\u2010evaluation of satisfaction for efficacy and safety. Adverse effects were also recorded after each treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total sixty patients completed the entire study. A significant improvement was observed in the appearance of acne scars, and the mean ECCA scores improved significantly after both modalities. The mean decrease in ECCA scores from the baseline was significantly more pronounced in fractional micro\u2010plasma RF as compared with fractional microneedle RF (41.33\u2009\u00b1\u200920.19 vs 32.17\u2009\u00b1\u200917.35; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The degree of clinical improvement was also significantly better for fractional micro\u2010plasma RF. Pain, erythema, and swelling were observed in all patients after both treatments. The pain was more intense during micro\u2010plasma RF treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.000), and the duration of pain and erythema were longer than with fractional microneedle RF (<jats:italic>P<\/jats:italic>\u2009=\u20090.000). Postinflammatory hyperpigmentation (PIH) was observed in one patient on the fractional micro\u2010plasma RF side while no PIH was observed on the fractional microneedle RF side. No infections or worsening of scarring was observed with either treatment. No subject was dissatisfied with the efficacy of either device. Rolling scars tended to respond better to fractional micro\u2010plasma RF treatment compared with fractional microneedle RF (<jats:italic>P<\/jats:italic>\u2009=\u20090.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both fractional micro\u2010plasma RF and fractional microneedle RF are effective and safe methods for improving atrophic acne scars. Fractional micro\u2010plasma RF is significantly more effective for atrophic acne scars, especially for rolling scars. However, fractional microneedle RF has fewer side effects plus shorter downtime, and patients are more comfortable after the treatment. Lasers Surg. Med. \u00a9 2020 Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23369","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T01:07:07Z","timestamp":1608253627000},"page":"906-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Comparison of Fractional Micro\u2010Plasma Radiofrequency and Fractional Microneedle Radiofrequency for the Treatment of Atrophic Acne Scars: A Pilot Randomized Split\u2010Face Clinical Study in China"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-9366","authenticated-orcid":false,"given":"Ting","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Southwest Hospital Army Medical University  Chongqing 400038 China"},{"name":"Department of Cosmetic Dermatology Luxury Skincenter  Xi'an 710048 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Southwest Hospital Army Medical University  Chongqing 400038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiai","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Southwest Hospital Army Medical University  Chongqing 400038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-4605","authenticated-orcid":false,"given":"Michael R.","family":"Hamblin","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine Massachusetts General Hospital  Boston Massachusetts 02114"},{"name":"Department of Dermatology Harvard Medical School  Boston Massachusetts 02115"},{"name":"Laser Research Centre, Faculty of Health Science University of Johannesburg  Doornfontein 2028 South 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