{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:09:37Z","timestamp":1773796177866,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Phototherapy for acne with a combination of blue and red light\u2010emitting diodes (LEDs) appears to have excellent potential in treating inflammatory acne. However, a standard twice\u2010weekly protocol administered 3 days apart may not be practical for patients. This study aims to seek the efficacy of LED treatment in moderate to severe acne, comparing between once and alternating twice\u2010weekly regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Thirty subjects with moderate to severe acne, as defined by Burton's grading score, were recruited in the study. The subjects were randomly divided into two groups\u2010 one group received alternating blue (470\u2009nm) and red (640\u2009nm) light in two visits per week for 4 consecutive weeks, while the other group got blue and red light treatments consecutively on the same visit for 4 consecutive weeks. During the study period, conventional treatments were prohibited. Clinical assessments were performed by lesion counts and blinded comparative photographs before treatment and at 1, 4, and 8 weeks after the final treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistically significant difference between once\u2010 and alternating twice\u2010weekly regimens. Both regimens provided marked improvement only for inflammatory lesions. The median percentage of acne reduction was significantly demonstrated for 1 week after finishing the course of treatment and was sustained until the end of the study. There were no side effects noted throughout the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LED therapy is safe and effective for treatment of inflammatory acne. The treatment outcomes of once and alternating twice\u2010weekly regimens were comparable, hence, once\u2010weekly treatment could be considered as an alternative choice for patient's convenience. Lasers Surg. Med. \u00a9 2021 Wiley Periodicals LLC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23388","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T19:41:30Z","timestamp":1612640490000},"page":"1080-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Comparative Study Between Once\u2010Weekly and Alternating Twice\u2010Weekly Regimen Using Blue (470\u2009nm) and Red (640\u2009nm) Light Combination LED Phototherapy for Moderate\u2010to\u2010Severe Acne Vulgaris"],"prefix":"10.1002","volume":"53","author":[{"given":"Sunatra","family":"Nitayavardhana","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok 10700 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