{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:38:03Z","timestamp":1788201483933,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>The long\u2010term efficacy of a picosecond alexandrite laser (PSAL) with a diffractive lens array (DLA) for the treatment of photoaging is absent. To observe the long\u2010term efficacy of PSAL for the treatment of photoaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Each patient (<jats:italic>n<\/jats:italic>\u2009=\u200910) received 10 treatments at 2\u2010week intervals. One side of the face was randomly selected for treatment. At 1, 3, 6, and 36 months after the final treatment, two blinded physicians evaluated photographs with four clinical indicators of photoaging (dyschromia, skin texture, skin laxity, and rhytids). A quartile scale was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, there were no significant differences in dyschromia, skin texture, facial laxity, or rhytids between the treated and control sides (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Picosecond laser\u2010treated side showed 0.85 and 1.05 (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) better for dyschromia at 3\u2010 and 6\u2010month follow\u2010up, and 0.6 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) better for skin texture at 6\u2010month follow\u2010up. At 36\u2010month follow\u2010up, the degree of photoaging is intensified on the control side while the rejuvenation efficacy maintained on the treated side, with 1.4, 0.75, and 0.8 (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) better for dyschromia, skin texture, and rhytids relative to the control side measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrate the long\u2010term efficacy and safety of PSAL with DLA for the treatment of facial photoaging. Limitation: Small sample size and the lack of objective evaluation. Lasers Surg. Med. \u00a9 2021 Wiley Periodicals LLC<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23393","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T23:04:14Z","timestamp":1613862254000},"page":"1065-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Three\u2010Year Results of Facial Photoaging in Asian Patients After Alexandrite 755\u2009nm Picosecond Laser With Diffractive Lens Array: A Split\u2010Face, Single\u2010Blinded, Randomized Controlled Comparison"],"prefix":"10.1002","volume":"53","author":[{"given":"Wenyou","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 China"},{"name":"Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 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