{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:09:09Z","timestamp":1773281349411,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Thermo\u2010mechanical fractional injury (TMFI) therapy (Tixel\u00ae; Novoxel\u00ae, Netanya, Israel) is an innovative technology. Along with its drug delivery enhancement features, it is widely used for facial skin rejuvenation. Our study explores the beneficial effect of the Tixel\u00ae on the different features of facial skin rejuvenation along with patients\u2032 satisfaction rate, aiming to suggest practical recommendations for an optimal aesthetic result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>A retrospective chart review of 24 patients (20 women, 4 men, average age 56 years old) with skin types II\u2013V who received 2 or 3 Tixel\u00ae treatments, 3\u20135 weeks apart in two medical centers (12 from Israel, 12 from the United Kingdom). Four experienced dermatologists compared standardized clinical photographs taken before each treatment and 3 months after the final treatment based on seven parameters that were set by 10 physicians and rated the difference on a scale of \u22121 to 4. Furthermore, epidemiology, treatment data, satisfaction, and safety were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the seven parameters that were compared (blood vessels and erythema, skin complexion, periorbital wrinkles, pigmentation and toning, pore size, vitality, wrinkles, and laxity), all features demonstrated an overall improvement, with the greatest improvement demonstrated in skin complexion (2.1\u2009\u00b1\u20090.49) and periorbital wrinkling (2.09\u2009\u00b1\u20090.65) followed by vitality (1.7\u2009\u00b1\u20090.49). Side effects were transient, including erythema and hyperpigmentation, and the average downtime was 1.7 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TMFI is a safe and effective method for\u00a0improving facial skin quality. Addressing patient\u2032s expectations while maximizing the benefits of this novel technology will provide superior aesthetical results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23400","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T14:58:48Z","timestamp":1617116328000},"page":"1152-1157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Thermo\u2010Mechanical Fractional Injury Therapy for Facial Skin Rejuvenation in Skin Types II to V: A Retrospective Double\u2010Center Chart Review"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8852-9384","authenticated-orcid":false,"given":"Danny","family":"Daniely","sequence":"first","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv 642906 Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 6997801 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harryono","family":"Judodihardjo","sequence":"additional","affiliation":[{"name":"Belgravia Dermatology Limited  London SW1X 9AE UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad F.","family":"Rajpar","sequence":"additional","affiliation":[{"name":"Belgravia Dermatology Limited  London SW1X 9AE UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-7075","authenticated-orcid":false,"given":"Joseph N.","family":"Mehrabi","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 6997801 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-5843","authenticated-orcid":false,"given":"Ofir","family":"Artzi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv 642906 Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv 6997801 Israel"},{"name":"Dr. Artzi and Associates \u2010 Treatment and Research Center  Tel Aviv 6997712 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"issue":"6","key":"e_1_2_6_2_1","first-page":"s104","article-title":"The future of non\u2010invasive rejuvenation technology: Devices","volume":"16","author":"Gold MH","year":"2017","journal-title":"J Drugs 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