{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:12:22Z","timestamp":1760249542650,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Meticulous dissection and identification of nerves during head and neck surgery are crucial for preventing nerve damage. At present, nerve identification relies heavily on the surgeon's knowledge of anatomy, optionally combined with intraoperative neuromonitoring. Recently, optical techniques such as Mueller polarimetric imaging (MPI) have shown potential to improve nerve identification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>With institutional approval, seven 25\u201335\u2009kg Yorkshire pigs underwent cervical incision in the central neck. Intraoperative images were obtained using our in\u2010house MPI system. Birefringence maps from the MPI system were processed to quantify the values between 0 and 255 from different tissue types; an active contour model was applied to further improve nerve visualization on the corresponding color images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the seven pigs, the vagus nerves\u00a0and recurrent laryngeal nerves\u00a0were successfully differentiated with a mean intensity of 130.954\u2009\u00b1\u200920.611, which was significantly different (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) from those of arteries (78.512\u2009\u00b1\u200927.78) and other surrounding tissues (82.583\u2009\u00b1\u200935.547). There were no imaging\u2010related complications during the procedure. \u00a9 2021 Wiley Periodicals LLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MPI is a potentially complementary intraoperative tool for nerve identification in adjacent tissues.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23422","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T07:41:06Z","timestamp":1622014866000},"page":"1427-1434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Improved Nerve Visualization in Head and Neck Surgery Using Mueller Polarimetric Imaging: Preclinical Feasibility Study in a Swine Model"],"prefix":"10.1002","volume":"53","author":[{"given":"Bo","family":"Ning","sequence":"first","affiliation":[{"name":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, 111 Michigan Avenue NW  Washington,\u00a0District of Columbia 20010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Kyungpook National University Chilgok Hospital  807 Hoguk\u2010ro Buk\u2010gu Daegu 41404 South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itai","family":"Katz","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, 111 Michigan Avenue NW  Washington,\u00a0District of Columbia 20010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering George Washington University  800 22nd Street NW Washington,\u00a0District of Columbia 20052"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Sandler","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, 111 Michigan Avenue NW  Washington,\u00a0District of Columbia 20010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-1464","authenticated-orcid":false,"given":"Jaepyeong","family":"Cha","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, 111 Michigan Avenue NW  Washington,\u00a0District of Columbia 20010"},{"name":"Department of Pediatrics George Washington University School of Medicine and Health Sciences  2300 I St NW Washington,\u00a0District of Columbia 20052"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"issue":"16","key":"e_1_2_7_2_1","first-page":"273","article-title":"Iatrogenic nerve injuries: Prevalence, diagnosis and treatment","volume":"111","author":"Antoniadis G","year":"2014","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.135.2.204"},{"key":"e_1_2_7_4_1","first-page":"152","article-title":"Complications and sequelae of thyroidectomy and an analysis of surgeon experience and outcome","volume":"12","author":"Mittendorf EA","year":"2004","journal-title":"Surg Technol Int"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.07.017"},{"key":"e_1_2_7_6_1","first-page":"91","article-title":"Evidence\u2010based analysis on the clinical impact of intraoperative neuromonitoring in thyroid surgery: State of the art and future perspectives","volume":"25","author":"Mangano A","year":"2014","journal-title":"Surg Technol Int"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.08.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0457"},{"issue":"1","key":"e_1_2_7_9_1","first-page":"19","article-title":"Loss of signal in recurrent nerve neuromonitoring: Causes and management","volume":"4","author":"Wu C\u2010W","year":"2015","journal-title":"Gland Surg"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.18019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00995-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.17.5.056012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22369"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay0712"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.8696"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","unstructured":"KumamotoY MinamikawaT KawamuraA et al. 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