{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:28:51Z","timestamp":1790659731360,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To evaluate the efficacy and safety of fractional 1064\u2009nm Nd:YAG picosecond laser combined with intense pulsed light (IPL) in the treatment of atrophic acne scar with post\u2010inflammatory erythema (PIE). \u00a9 2021 Wiley Periodicals LLC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Seventeen patients received five sessions of treatment at weeks 0, 4, 8, 12, 16 and were followed up at week 28. One half of the face was randomly treated by fractional 1064\u2009nm Nd:YAG picosecond laser combined with IPL (FxPico\u2009+\u2009IPL), and the other by IPL alone as a control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the 15 patients who completed the study, the FxPico\u2009+\u2009IPL side demonstrated significant median \u00c9chelle D'\u00e9valuation clinique des cicatrices D'acn\u00e9 (ECCA) score improvement (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), while IPL alone side did not (<jats:italic>P<\/jats:italic>\u2009=\u20090.1250). The pore counts for both sides decreased but more pore count reduction was seen on the FxPico\u2009+\u2009IPL side (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Better scar improvement was observed on the FxPico\u2009+\u2009IPL\u2010treated side (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) while no difference in erythema improvement was seen between the two sides. There was no difference between the two treatments in terms of overall satisfaction. Pain, erythema, edema, petechiae, crusting, reactive acneiform eruptions, and pruritus were common adverse effects and were mild to moderate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FxPico\u2009+\u2009IPL is an effective, efficient, and safe treatment regimen for atrophic acne scars complicated by PIE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23428","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T12:31:45Z","timestamp":1622809905000},"page":"1356-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Efficacy and Safety of Fractional 1064 nm Nd:YAG Picosecond Laser Combined With Intense Pulsed Light in the Treatment of Atrophic Acne Scar: A Split\u2010Face Study"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-6083","authenticated-orcid":false,"given":"Hao","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College Fudan University 12 Wulumuqi Road Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College Fudan University 12 Wulumuqi Road Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College Fudan University 12 Wulumuqi Road Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College Fudan University 12 Wulumuqi Road Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxian","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College Fudan University 12 Wulumuqi Road Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Shanghai Medical College Fudan University 12 Wulumuqi Road Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)80056-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1164"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12885"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"97","article-title":"Prevalence and risk factors of acne scarring among patients consulting dermatologists in the USA","volume":"16","author":"Tan J","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2006.00079.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113451"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16680"},{"issue":"6","key":"e_1_2_7_9_1","first-page":"566","article-title":"Prospective study of pathogenesis of atrophic acne scars and role of macular erythema","volume":"16","author":"Tan J","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_10_1","unstructured":"SaediN UebelhoerN. 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