{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:29:31Z","timestamp":1788427771441,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Skin rejuvenation with radiofrequency has been a widely used treatment modality for the safe and efficient remodeling of the dermis and revision of textural irregularities, achieved with minimal downtime. The efficacy of fractional radiofrequency (FRF) specifically for acne scarring has not been widely established. The objective of this clinical trial was to establish the efficacy and safety of FRF for moderate to severe acne scarring in a wide range of Fitzpatrick skin types using two different applicator tips to deliver energy to the skin (80\u2010pin of up to 124\u2009mJ\/pin and 160\u2010pin of up to 62\u2009mJ\/pin).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Enrolled subjects received a series of three FRF treatments to the full face, each 4 weeks apart. A visual analog scale was utilized to assess pain of the treatment. Subject satisfaction questionnaires were completed at follow\u2010up visits at 6 and 12 weeks post final treatment. Photographs were graded for change by three blinded evaluators using the Global Aesthetic Improvement Scale (GAIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Image sets of 23 enrolled subjects were assessed by blinded evaluation, showing a statistically significant improvement (<jats:italic>p<\/jats:italic>\u2009=\u20090.009) from the baseline visit to the 12\u2010week follow\u2010up on the GAIS for acne scarring. Subject satisfaction was high with subjects giving an average satisfaction score of 3.27 (\u201csatisfied\u201d) out of 4. Pain was \u201cmild\u201d as treatments were rated an average of 2.15 on a 10\u2010point visual analog scale. The GAIS score of the 80\u2010pin tip improved patients' acne scars treated with that applicator by 1.06 points and 0.85 for the 160\u2010pin tip. Ninety\u2010five percent (95.5%) of subjects reported either a mild, moderate, or significant improvement to their treatment area. Ninety\u2010one percent of subjects reported that they would recommend the treatment to a friend.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FRF produced a statistically significant improvement in acne scarring when assessed by independent blinded evaluators. No serious adverse events resulted from treatment by either applicator tip. Treatment pain was low and tolerable among subjects of all Fitzpatrick skin types. Subjects had high levels of satisfaction with the results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23453","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T23:10:58Z","timestamp":1629414658000},"page":"74-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Safety and efficacy of fractional radiofrequency for the treatment and reduction of acne scarring: A prospective study"],"prefix":"10.1002","volume":"54","author":[{"given":"Stephen W.","family":"Eubanks","sequence":"first","affiliation":[{"name":"Ameriderm Research Leavitt Medical Associates of Florida Port Orange Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7193-5917","authenticated-orcid":false,"given":"James A.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Ameriderm Research Leavitt Medical Associates of Florida Port Orange Florida USA"},{"name":"College of Medicine University of Central Florida Orlando Florida USA"},{"name":"College of Medicine Florida State University Orlando Florida USA"},{"name":"Department of Dermatology Carle\u2010Illinois College of Medicine Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.29"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10081049"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_565_17"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14586"},{"key":"e_1_2_7_6_1","unstructured":"AkaishiS KoikeS DohiT KobeK HyakusokuH OgawaR. 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