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A total of 71 breast cancer patients planned to undergo HF\u2010WBI were randomized to one of the two study arms: the control group (<jats:italic>n<\/jats:italic>\u2009=\u200932) or the PBM group (<jats:italic>n<\/jats:italic>\u2009=\u200939). The PBM group received the standard institutional skincare combined with PBM (2\u00d7\/week) during the complete radiotherapy (RT) course. Patients in the control group received the standard skincare combined with placebo treatment (2x\/week). Patients' skin reactions were evaluated weekly during the RT treatment by using the modified version of the Radiation Therapy Oncology Group (RTOG) criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At week 3 of RT, one patient presented a grade 2 and one patient a grade 3 skin reaction in the control group, while in the PBM group, all patients still presented grade 1 ARD. At the final RT session 28% of the patients presenting grade 2\u20133 ARD, while in the PBM group 10% presented grade 2 and no grade 3 ARD. PBM reduced the incidence of severe ARD by 18%. However, the difference was not significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.053).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the LABRA trial results, PBM seems not able to reduce the incidence of severe ARD in breast cancer patients undergoing HF\u2010WBI. Research in a larger patient population is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23475","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T21:24:30Z","timestamp":1630790670000},"page":"374-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast cancer patients undergoing hypofractioned whole\u2010breast irradiation (LABRA trial)"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-1581","authenticated-orcid":false,"given":"Jolien","family":"Robijns","sequence":"first","affiliation":[{"name":"Faculty of Medicine &amp; Life Sciences Hasselt University Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Lodewijckx","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Life Sciences Hasselt University Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Puts","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; 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