{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:44:37Z","timestamp":1790671477720,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Light\u2010emitting diodes (LEDs) in the visible or near\u2010infrared spectrum have been reported to promote wound healing. However, despite being frequently proposed in daily clinical practice, the efficacy of photobiomodulation treatment after a laser procedure relies on very limited clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the relative efficacy of LED versus placebo treatment in decreasing erythema and transepidermal water loss (TEWL) after a fractional CO<jats:sub>2<\/jats:sub> session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an open prospective intraindividual randomized controlled study with 10 healthy volunteers. An ablative fractional laser was performed on the seven forearm areas. Three consecutive daily sessions of LED (590, 630, and 850\u2009nm [two tested irradiances each] and placebo) were applied after randomization. Physical measures (colorimetry, TEWL), photography, and clinical evaluation were performed on Days 1, 2, 3, 7, and 21. The main criterion of evaluation was the variation of parameter a* (erythema) at 72\u2009hours for each LED parameter compared to placebo treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in the variation of the parameter a* or any of the other studied parameters were found for the different LEDs compared to the placebo area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Photobiomodulation failed to improve healing after laser ablation compared to placebo.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23480","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T20:00:46Z","timestamp":1631822446000},"page":"342-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["HeaLED: Assessment of skin healing under light\u2010emitting diode (LED) exposure\u2014A randomized controlled study versus placebo"],"prefix":"10.1002","volume":"54","author":[{"given":"Florence","family":"Le Duff","sequence":"first","affiliation":[{"name":"Dermatology Department, Archet Hospital\u2014CHU University C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Fontas","sequence":"additional","affiliation":[{"name":"D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'innovation (DRCI), Universit\u00e9 C\u00f4te D'Azur CHU Nice  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Guardoli","sequence":"additional","affiliation":[{"name":"Dermatology Department, Archet Hospital\u2014CHU University C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Philippe","family":"Lacour","sequence":"additional","affiliation":[{"name":"Dermatology Department, Archet Hospital\u2014CHU University C\u00f4te d'Azur  Nice 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