{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T22:26:35Z","timestamp":1772317595486,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014055","name":"U.S. Army Medical Research Acquisition Activity","doi-asserted-by":"publisher","award":["Award W81XWH\u201017\u20101\u20100388 (Joint Warfighter)"],"award-info":[{"award-number":["Award W81XWH\u201017\u20101\u20100388 (Joint Warfighter)"]}],"id":[{"id":"10.13039\/100014055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastrointestinal anastomotic leakage is a dreaded complication despite advancements in surgical technique. Photochemical tissue bonding (PTB) is a method of sealing tissue surfaces utilizing photoactive dye. We evaluated if crosslinked human amniotic membrane (xHAM) photosealed over the enteroenterostomy would augment anastomotic strength in a trauma\u2010relevant swine hemorrhagic shock model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Yorkshire swine (40\u201345\u2009kg, <jats:italic>n<\/jats:italic>\u2009=\u200914) underwent midline laparotomy and sharp transection of the small intestine 120\u2009cm proximal to the ileocecal fold. Immediately following intestinal transection, a controlled arterial bleed was performed to reach hemorrhagic shock. Intestinal repair was performed after 60\u2009minutes and autotransfusion of the withdrawn blood was performed for resuscitation. Animals were randomized to small intestinal anastomosis by one of the following methods (seven per group): suture repair (SR), or SR with PTB augmentation. Animals were euthanized at postoperative Day 28 and burst pressure (BP) strength testing was performed on all excised specimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean BP for SR, PTB, and native tissue groups were 229\u2009\u00b1\u200940, 282\u2009\u00b1\u200921, and 282\u2009\u00b1\u200947\u2009mmHg, respectively, with the SR group statistically significantly different on analysis of variance (<jats:italic>p<\/jats:italic>\u2009=\u20090.02). Post\u2010hoc Tukey all\u2010pairs comparison demonstrated a statistically significant difference in burst pressure strength between the SR only and the PTB group (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). All specimens in SR group ruptured at the anastomosis upon burst pressure testing, while all specimens in the PTB group ruptured at least 2.5\u2009cm from the anastomosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Photosealing with xHAM significantly augments the strength of small intestinal anastomosis performed in a trauma porcine model.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23485","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T09:46:07Z","timestamp":1634809567000},"page":"407-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Light\u2010activated photosealing with human amniotic membrane strengthens bowel anastomosis in a hypotensive, trauma\u2010relevant swine model"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-3694","authenticated-orcid":false,"given":"Benjamin B.","family":"Scott","sequence":"first","affiliation":[{"name":"Wellman Center for Photomedicine, Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Plastic Surgery Research Laboratory, Department of Surgery, Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3328-3222","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3725-5931","authenticated-orcid":false,"given":"Ruby C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-9832","authenticated-orcid":false,"given":"Mark A.","family":"Randolph","sequence":"additional","affiliation":[{"name":"Plastic Surgery Research Laboratory, Department of Surgery, Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-430X","authenticated-orcid":false,"given":"Robert W.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Wellman Center for Photomedicine, Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000225083.27182.85"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.11.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-016-1556-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2004.00657.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-001-0256-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.10.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481107700929"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yasu.2016.03.011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.07.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00615.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.01165.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182050eb7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000060248.87046.EE"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.07.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000093243.01377.9B"},{"issue":"5","key":"e_1_2_7_17_1","article-title":"A profile of combat injury","volume":"54","author":"Champion HR","year":"2003","journal-title":"J Trauma"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usy009"},{"issue":"4","key":"e_1_2_7_19_1","first-page":"1043","article-title":"Management of colorectal injuries during operation iraqi freedom: patterns of stoma usage","volume":"64","author":"Duncan JE","year":"2008","journal-title":"J Trauma"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.06.040"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-9-47"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/08941930701772173"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1158-z"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13162811"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-200007000-00007"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-009-0637-y"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-0212-y"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31488"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6739-2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2018.0003"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20869"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.13126"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20548"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.11.005"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2007.01.028"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.01.025"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001617"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6516"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20221"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.09.019"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22066"},{"issue":"11","key":"e_1_2_7_42_1","first-page":"3335","article-title":"Photochemical keratodesmos for repair of lamellar corneal incisions","volume":"41","author":"Mulroy L","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.02.068"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1066"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21083"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21797"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22507"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.04.007"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/145749691210100403"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-014-0982-5"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510160502"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420009156"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90107-0"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.01.004"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.3181\/0709-MR-262"},{"key":"e_1_2_7_56_1","volume-title":"Nutritional physiology of pigs","author":"L\u00e6rke H","year":"2012"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2006.03.006"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(01)80052-4"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2020.587951"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1080\/08941930802713001"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350611418254"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/lsm.23485","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:14:06Z","timestamp":1692965646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/lsm.23485"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23485","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,19]]},"assertion":[{"value":"2021-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}