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By altering the skin barrier, ablative fractional lasers (AFLs) enhance cutaneous uptake of the synergistic chemotherapeutic agents, cisplatin, and 5\u2010fluorouracil (5\u2010FU). In our recently reported clinical trial, AFL\u2010assisted delivery of cisplatin and 5\u2010FU showed favorable short\u2010term clearance rates of 95% with good cosmetic results at 3 months. This follow\u2010up study assessed sustained tumor clearance, safety, and cosmesis in the same patient cohort, observed 6\u2010 and 12\u2010months posttreatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This follow\u2010up study assessed AFL\u2010assisted cisplatin and 5\u2010FU in low\u2010risk BCC. Among the 18\/19 patients who achieved clinical tumor clearance in our 3\u2010months primary trial, all were included for a 6\u2010months follow\u2010up. At 12 months, 17\/19 were included due to one 6\u2010month residual. During follow\u2010up visits, treated areas were evaluated for signs of recurrent tumour by clinical inspection and optical coherence tomography (OCT). Residual tumors were confirmed histologically. Cosmetic outcome was evaluated at both follow\u2010up visits by patients and physicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, complete tumor clearance was 89% (17\/19) and 79% (15\/19) at 6 and 12 months, respectively. Clearance rate for superficial BCCs (sBCCs) 1 year after treatment was 100% (6\/6) and lower for nodular BCC (nBCC) at 69% (9\/13). Among recurrent tumors, 67% (2\/3) had received only a single treatment and all were of the nodular subtype, situated in the head and neck area. All histologically confirmed BCC recurrences were identified by OCT. Cosmetic outcomes were similarly rated \u201cgood\u201d or \u201cexcellent\u201d by patients and evaluators (<jats:italic>p<\/jats:italic>\u2009=\u20090.289 and <jats:italic>p<\/jats:italic>\u2009=\u20090.250). Treatment\u2010related local skin reactions were mild and tolerable, consisting of persisting erythema in two patients at the end of the study. Dyspigmentation was commonly observed at both follow\u2010up visits, while the appearance of scarring resolved in the majority of patients between 6 months (56%; 10\/18) and 12 months (76%; 13\/17).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AFL\u2010assisted cisplatin\u2009+\u20095\u2010FU in double sessions represents an acceptable and safe treatment strategy for low\u2010risk sBCC, while clearance rates following single treatment or for nBCC seem inferior. This intensified topical strategy may be best suited to cases of multiple lesions or in instances where surgical excision or extended courses of at\u2010home therapy is challenging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23497","type":"journal-article","created":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T15:29:45Z","timestamp":1638718185000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy and safety of laser\u2010assisted combination chemotherapy: A follow\u2010up study of treatment with 5\u2010fluorouracil and cisplatin for basal cell carcinoma"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-2651","authenticated-orcid":false,"given":"Gabriella","family":"Fredman","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital University of Copenhagen Copenhagen 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