{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:58:30Z","timestamp":1790222310892,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME 5482\/1\u20101"],"award-info":[{"award-number":["ME 5482\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphedema is a frequent debilitating condition among cancer patients. Daily supportive treatment may be necessary without long\u2010term improvement. We describe two cases with chronic refractory lymphedema treated with fractional 10,600\u2009nm CO<jats:sub>2<\/jats:sub> laser. A 61\u2010year\u2010old female with locally advanced cervical cancer presented with postsurgical edematous swelling of the vulva and mons pubis and recurring cellulitis due to chronic lymphangiectasia. After six treatments of fractional CO<jats:sub>2<\/jats:sub> laser, she noticed an 80% reduction of lymphorrea, swelling, and frequency of cellulitis. A 32\u2010year old melanoma patient presented with refractory right lower leg lymphedema post right inguinal lymph node dissection and radiation. After fractional CO<jats:sub>2<\/jats:sub> laser, she noted increased softness of her inguinal scar and a decrease of the lower leg edema. Fractional CO<jats:sub>2<\/jats:sub> laser may be useful in addressing chronic refractory lymphedema. Further research should confirm our findings to consider fractional laser as a standard method in the treatment of chronic lymphedema.<\/jats:p>","DOI":"10.1002\/lsm.23498","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T10:30:02Z","timestamp":1638009002000},"page":"337-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of laser CO<sub>2<\/sub> treatment for refractory lymphedema secondary to cancer treatments"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-0191","authenticated-orcid":false,"given":"Christian","family":"Menzer","sequence":"first","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Aleisa","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britney N.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenara","family":"Musthaq","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2295-1934","authenticated-orcid":false,"given":"Anthony","family":"Rossi","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Dermatology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2019-001032"},{"issue":"20","key":"e_1_2_5_3_1","article-title":"Overview of lymphedema for physicians and other clinicians: a review of fundamental concepts","volume":"0025","author":"Manrique OJ","year":"2020","journal-title":"Mayo Clin 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