{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T01:36:09Z","timestamp":1763429769448,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The formation of hypertrophic scar is due to the abnormal accumulation and remodeling of the extracellular matrix, especially collagen tissue. Our research was designed to investigate the treatment effect of different administrations of human umbilical cord\u2010derived stem cells and to hypertrophic scars on rabbit ears.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty New Zealand female white rabbits were treated as hypertrophic scar models. PBS was injected into the scars on the right ear of each group as control, while human umbilical cord\u2010derived stem cells or condition medium of human umbilical cord\u2010derived stem cells were administrated into the left ear through subcutaneous injection or fractional laser\u2010assisted administration. Gross examination, scar elevation index (SEI) calculation and sampling were executed 5 weeks after administration. Then H&amp;E and Masson staining analysis and the expression levels detections of \u03b1\u2010SMA, Collagen I, TGF\u2010\u03b21, IL\u20101\u03b2, and IL\u20106 were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results demonstrated that the severity of hyperplasia was lower than the model group after stem cells and conditioned medium treatment. H&amp;E and Masson staining results showed that the inflammation in scars was greatly alleviated and the degree of fibrosis was reduced after treatment. There was no significant difference in the therapeutic effect between subcutaneous injection or fractional laser\u2010assisted administration. Both stem cells and conditioned medium can down\u2010regulate SEI and factors expression levels in all groups. However, compared with the stem cells, the therapeutic effects of the conditioned medium were lower.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results confirmed that stem cells had an available treatment effect on hypertrophic scars of rabbit ears. In addition to the paracrine pathway, stem cells may have other ways to treat hypertrophic scars. Fractional laser\u2010assisted administration may become a potential administration of stem cell clinical application in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23508","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T10:11:28Z","timestamp":1640686288000},"page":"554-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fractional laser\u2010assisted administration of human umbilical cord mesenchymal stem cells to reduce hypertrophic scars in rabbit ears"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-4481","authenticated-orcid":false,"given":"Hongpeng","family":"Zhang","sequence":"first","affiliation":[{"name":"R&amp;D Department Asia Stem Cell Regenerative Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"R&amp;D Department Asia Stem Cell Regenerative Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuibao","family":"Jiang","sequence":"additional","affiliation":[{"name":"R&amp;D Department Asia Stem Cell Regenerative Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[{"name":"R&amp;D Department Asia Stem Cell Regenerative Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xia","sequence":"additional","affiliation":[{"name":"R&amp;D Department Asia Stem Cell Regenerative Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danpeng","family":"Shen","sequence":"additional","affiliation":[{"name":"R&amp;D Department Asia Stem Cell Regenerative Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Xie","sequence":"additional","affiliation":[{"name":"R&amp;D Department Asia Stem Cell Regenerative Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nianmin","family":"Qi","sequence":"additional","affiliation":[{"name":"R&amp;D Department Asia Stem Cell Regenerative Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000527576.27489.0f"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030606"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.02.017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.169"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"FriedmanR BetancurM&BoisselLet al. Umbilical cord mesenchymal stem cells: adjuvants for human cell transplantation.[J]. 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