{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:33:39Z","timestamp":1788377619366,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Disruption of the natural skin barrier in a controlled manner may be used to deliver drugs that enhance scar resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy and safety of thermomechanical fractional injury (TMFI)\u2010assisted topical corticosteroid delivery with corticosteroid injection in the treatment of hypertrophic scar (HTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a randomized, split\u2010scar, double\u2010blinded study. Twenty\u2010one subjects with HTS on the abdomen received five split\u2010scar treatments of TMFI\u2009+\u2009Steroid and steroid injection alone. Changes in scar thickness, scar volume, and Vancouver Scar Scale (VSS) were analyzed. Patient self\u2010assessment, VAS scores, and adverse effects were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Scar thickness, volume, and VSS scores of both segments improved significantly compared to baseline. On every follow\u2010up visit, there were no significant differences in mean scar thickness reduction between the two treatment groups except at the 6\u2010month follow\u2010up where the mean scar thickness reduction of the steroid injection segment was significantly lower than that of the TMFI\u2009+\u2009Steroid segment (95% confidence interval [CI], 0.09\u20130.35; <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Scar volume, VSS scores, and patient self\u2010assessment also showed no significant differences between both segments on all visits. The steroid injection segment was significantly more painful than the TMFI\u2009+\u2009Steroid segment (95% CI, \u22122.16 to \u22121.29; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Adverse effects of skin atrophy, telangiectasia, and post\u2010inflammatory hyperpigmentation were noted in the steroid injection segment, while no adverse effects were observed at the TMFI\u2009+\u2009Steroid segment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TMFI\u2010assisted topical corticosteroid delivery is an effective treatment for HTS with a lower risk of adverse effects compared with corticosteroid injection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23511","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T11:01:59Z","timestamp":1639652519000},"page":"483-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and safety of thermomechanical fractional injury\u2010assisted corticosteroid delivery versus intralesional corticosteroid injection for the treatment of hypertrophic scars: A randomized split\u2010scar trial"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-7963","authenticated-orcid":false,"given":"Woraphong","family":"Manuskiatti","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadakan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Artzi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tel Aviv Sourasky Medical Center  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia Katrina R.","family":"Gervasio","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University 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