{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:45Z","timestamp":1786978185963,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>To evaluate the clinical efficacy and safety of 5\u2010aminolevulinic acid photodynamic therapy (ALA\u2010PDT) in the treatment of patients with positive margin in comparison to regular follow\u2010up, and a repeat cervical conization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted using 83 patients with pathologically confirmed high\u2010grade cervical intraepithelial neoplasia (CIN) with a positive margin after conization. The management methods and patient prognosis were analyzed and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010five, 33, and 15 patients were treated for regular follow\u2010up, ALA\u2010PDT, and a repeat cervical conization, respectively. About 33.3% (5\/15) patients had residual lesions of low\u2010grade CIN and above after recognization. The clinical characteristics of patients in the three groups were similar. The residual lesion rates of patients selected for follow\u2010up, ALA\u2010PDT, and recognization were 34.3% (12\/35), 9.1% (3\/33), and 0% (0\/15), respectively, at 6\u2010month follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). The HPV clearance rates were 31.3%, 66.7%, and 84.6%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Further analysis showed that a positive margin in the inscribed margin of the cervical canal (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) and persistent HR\u2010HPV positive tests after initial conization (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) significantly increased the risk of residual disease. At 2\u2010year follow\u2010up, the recurrence rates of lesions were 3.3% and 26.1% in the ALA\u2010PDT and follow\u2010up groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). Notably, the recurrence rates were not significantly different between the ALA\u2010PDT and recognization groups (3.3% vs. 6.7%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.561).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ALA\u2010PDT is an effective treatment for patients with a positive margin after cervical conization for high\u2010grade CIN. Compared with regular follow\u2010up, ALA\u2010PDT can reduce residual and recurrence rate. Moreover, there was no significant difference in the efficacy between AlA\u2010PDT and recognization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.23585","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T03:12:58Z","timestamp":1657509178000},"page":"1099-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Management of patients with positive margin after conization for high\u2010grade cervical intraepithelial lesions"],"prefix":"10.1002","volume":"54","author":[{"given":"Yingcui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehui","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-7320","authenticated-orcid":false,"given":"Mengzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000525"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012792"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30700-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.05.027"},{"key":"e_1_2_8_6_1","article-title":"Long\u2010term clinical outcome after treatment for high\u2010grade cervical lesions: a retrospective monoinstitutional cohort study","volume":"2015","author":"Del MA","year":"2015","journal-title":"BioMed Res Int"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2013.46.1.7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102293"},{"issue":"16","key":"e_1_2_8_9_1","first-page":"4751","article-title":"5\u2010aminolevulinic acid photodynamic therapy for cervical intraepithelial neoplasia class I","volume":"5","author":"Xiuli W","year":"2011","journal-title":"Chinese J Clin"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"100","article-title":"A lectin\u2010based diagnostic system using circulating antibodies to detect cervical intraepithelial neoplasia and cervical cancer","volume":"26","author":"Jin Y","year":"2016","journal-title":"Glycobiology"},{"issue":"17","key":"e_1_2_8_11_1","first-page":"2808","article-title":"Value of re cervical conization in the treatment of residual or recurrent cervical intraepithelial neoplasia","volume":"29","author":"Liu M","year":"2014","journal-title":"China Mater Child Health Care"},{"issue":"07","key":"e_1_2_8_12_1","first-page":"604","article-title":"Management and follow\u2010up of high\u2010grade squamous intraepithelial lesions of cervix","volume":"36","author":"Shu LG","year":"2020","journal-title":"Chin J Exp Gynecol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.11.023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12064"},{"key":"e_1_2_8_15_1","volume-title":"Colposcopy and programme management. Guidelines for the NHS cervical screening programme","author":"Luesley DLS","year":"2010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-017-0517-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.09.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.01.015"},{"issue":"09","key":"e_1_2_8_19_1","first-page":"680","article-title":"Changes and significance of LEEP in the treatment of high\u2010risk HPV after cervical intraepithelial neoplasia","volume":"19","author":"Jing Ji","year":"2010","journal-title":"Prog\u00a0Modern Obstet Gynecol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25745"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S81802"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2021.102634"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23585","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:31:10Z","timestamp":1692743470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,11]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/lsm.23585"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23585","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,11]]},"assertion":[{"value":"2021-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}