{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:53:12Z","timestamp":1790146392759,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>New and improved treatment modalities, including lasers and energy\u2010based devices, are promising treatment options for hypertrophic scars. This study aimed to assess the efficacy and safety of fractional microneedle radiofrequency (FMR) compared with fractional carbon dioxide (CO<jats:sub>2<\/jats:sub>) laser in the treatment of postburn hypertrophic scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Twenty patients with hypertrophic scars were enrolled in the study. Two areas in each patient were randomly assigned to fractional CO<jats:sub>2<\/jats:sub> laser or FMR. Four sessions, 6\u20138 weeks apart were performed. The Patient and Observer Scar Assessment Scale (POSAS) was used for clinical evaluation, H &amp; E and orcein\u2010stained samples were examined for histopathological assessment, and tissue transforming growth factor beta 1 (TGF\u03b2<jats:sub>1<\/jats:sub>) levels were measured for biochemical evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both fractional CO<jats:sub>2<\/jats:sub> and FMR\u2010treated areas showed significant improvement in all parameters 1 month after treatment. Fractional CO2\u2010treated areas showed a higher degree of improvement compared with FMR in OSAS (<jats:italic>p<\/jats:italic>\u2009=\u20090.025), elastin grading (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), and TGF\u03b2<jats:sub>1<\/jats:sub> levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.000). Patients reported less downtime and showed less postinflammatory hyperpigmentation with FMR compared with fractional CO<jats:sub>2,<\/jats:sub> but this did not reach statistical significance (<jats:italic>p<\/jats:italic>\u2009=\u20090.327, <jats:italic>p<\/jats:italic>\u2009=\u20090.231; respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrate the value of FMR as an effective alternative to fractional CO<jats:sub>2<\/jats:sub> in the treatment of hypertrophic scars, with a potentially favorable safety profile.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23589","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T15:17:59Z","timestamp":1659021479000},"page":"1089-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Fractional microneedle radiofrequency versus fractional carbon dioxide laser in the treatment of postburn hypertrophic scars"],"prefix":"10.1002","volume":"54","author":[{"given":"Shereen O.","family":"Tawfic","sequence":"first","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akmal S.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"El\u2010Zahraa SH Aly","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Elbendary","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfat G.","family":"Shaker","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Department, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-2912","authenticated-orcid":false,"given":"Aya M.","family":"AlOrbani","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08278.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00083"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01510.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20731"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584214"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.05.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02792-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16266"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12103"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.138328"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2016.1225964"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.20.139"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.98257.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00153"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000122207.28773.56"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.668"},{"issue":"12","key":"e_1_2_7_18_1","first-page":"614","article-title":"Biostatistics 104: correlational analysis","volume":"44","author":"Chan YH","year":"2003","journal-title":"Singapore Med J"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12292"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12398"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10225"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz055"},{"issue":"9","key":"e_1_2_7_23_1","first-page":"1044","article-title":"Surgical corner. 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