{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:15:20Z","timestamp":1781712920943,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Nevus of Ota is a benign melanocytic lesion that presents as a unilateral blue gray to brown facial patch favoring the distribution of the first two branches of the trigeminal nerve. Incidence is highest in Asian and Black populations, however, the overwhelming majority of studies are limited to diagnosis and treatment in Asian patients. We herein present 10 Black patients with Fitzpatrick skin types (FST) V and VI who underwent laser treatment for Nevus of Ota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of Black patients presenting with Nevus of Ota. Race was self\u2010designated by all patients and documented in the medical record at the time of initial consultation. Primary outcomes were based on improvement using before and after photographs which were graded by three independent board\u2010certified dermatologists using a 5\u2010point visual analog scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten FST\u00a0V or VI patients with an age range of 9 months to 45 years were treated for Nevus of Ota. All patients were treated with the 1064\u2009nm Q\u2010switched neodymium doped yttrium aluminum garnet (QS\u00a0Nd:YAG) and on average received 4.7 treatments at 2\u201310 month intervals. Fluence ranged from 1.8 to 2.3\u2009J\/cm<jats:sup>2<\/jats:sup>, and total pulse count ranged from 510.9 to 776.6. 2\/10 patients were additionally treated with 1550\u2009nm nonablative fractional resurfacing (NAFR), and 1\/10 patients underwent combination therapy with both\u00a0NAFR and 1064\u2009nm picosecond laser therapy. Overall, patients saw a mean improvement of 51%\u201375% at follow\u2010up 5\u2013254 weeks (mean 51.5 weeks) after treatment. Three patients experienced mild guttate hypopigmentation in treated areas. No other long\u2010term adverse events were encountered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>1064\u2009nm\u00a0QS Nd:YAG laser therapy is a safe and efficacious treatment for Nevus of Ota in patients with FST\u00a0V and VI. When patient improvement plateaus, combining therapy with 1550\u2009nm\u00a0NAFR or transitioning to 1064\u2009nm picosecond laser may be of benefit. Patients should be counseled on the risk of guttate hypopigmentation. This is the largest case series to date of Black patients with Nevus of Ota, highlighting the need for further investigation to determine optimal device settings and treatment parameters for this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23597","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T06:54:07Z","timestamp":1663656847000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment of Nevus of Ota in Black patients with the 1064\u2009nm QS or picosecond laser and nonablative fractional photothermolysis"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-8107","authenticated-orcid":false,"given":"Shelby L.","family":"Kubicki","sequence":"first","affiliation":[{"name":"Department of Dermatology, McGovern Medical School University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Guo","sequence":"additional","affiliation":[{"name":"Dermatology &amp; Laser Surgery Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Richmond","sequence":"additional","affiliation":[{"name":"Dermatology &amp; Laser Surgery Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, McGovern Medical School University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Dermatology &amp; Laser Surgery Center  Houston Texas USA"},{"name":"Department of Dermatology, Weill Cornell Medical College Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1967.01600320043006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.169"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.108208"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1961.01840020485004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34695-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12875"},{"key":"e_1_2_7_8_1","volume-title":"Dermatology","author":"Bolognia J","year":"2018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277339"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21121"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22757"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12085"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000212"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23421"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03125-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02000.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2007.49"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20254"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.182470"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05902.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34295.x"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23597","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23597","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:13:20Z","timestamp":1692587600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/lsm.23597"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23597","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,19]]},"assertion":[{"value":"2022-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}