{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:41:45Z","timestamp":1768434105111,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the effectiveness of long\u2010pulsed alexandrite laser (LPAL) with that of pulsed\u2010dye laser (PDL) for rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010blind randomized controlled trial on 27 patients who were clinically diagnosed with rosacea. Randomly assigned split face in each patient received four times monthly treatment of LPAL plus low\u2010fluence Nd:YAG with the contralateral side serving as the control treated with PDL. At every visit, the erythema index (EI) was measured with skin analysis systems, and two independent dermatologists evaluated digital photographs for five\u2010point global aesthetic improvement scale (GAIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The EI significantly decreased on both treated sides (LPAL 366.5\u2009\u00b1\u2009101.0 vs. 295.8\u2009\u00b1\u200990.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, PDL 369.0\u2009\u00b1\u2009124.3 vs. 302.7\u2009\u00b1\u200992.1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) 1 month after fourth\u00a0treatment (visit 5). Also 3 months after the fourth treatment (visit 6), the reduction in the EI was well maintained on both sides (LPAL 360.3\u2009\u00b1\u200996.8 vs. 282.0\u2009\u00b1\u200989.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, PDL 364.3\u2009\u00b1\u2009121.6 vs. 281.6\u2009\u00b1\u200997.8, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). When comparing the improvement in the EI between the two groups, the percentage reduction in the EI on the LPAL\u2010treated side was not inferior to the PDL\u2010treated side (visit 5: LPAL 18.7\u2009\u00b1\u200915.7% vs. PDL 16.4\u2009\u00b1\u200912.9%, <jats:italic>p<\/jats:italic>\u2009=\u20090.501 and visit 6: LPAL 21.7\u2009\u00b1\u200913.9% vs. PDL 21.9\u2009\u00b1\u200915.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.943). The GAIS and patient satisfaction were comparable between the LPAL and PDL sides and did not show any significant difference. No serious adverse events occurred on either of the treated sides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that the decrease in\u00a0EI in the treatment of rosacea was comparable between PDL and LPAL. Therefore, LPAL could be a promising alternative treatment option with good merits for rosacea, considering no consumables are required for device maintenance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23605","type":"journal-article","created":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T19:43:21Z","timestamp":1664739801000},"page":"1217-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A randomized split\u2010face comparative study of long\u2010pulsed alexandrite plus low\u2010fluence Nd:YAG laser versus pulsed\u2010dye laser in the treatment of rosacea"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-4402","authenticated-orcid":false,"given":"Sujin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine  Seoul 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College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Jeong","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-5941","authenticated-orcid":false,"given":"Jihee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine  Seoul Korea"},{"name":"Department of Dermatology Yongin Severance Hospital  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