{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:49:35Z","timestamp":1790005775476,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The evidence demonstrating the efficacy of photobiomodulation (PBM) therapy for preventing and managing acute radiation dermatitis (ARD) is growing steadily. The question that arises from many clinicians is, if PBM is safe for oncologic patients. This study aimed to evaluate the disease\u2010free survival (DFS), cancer\u2010free survival (CFS), and overall survival (OS) of breast cancer patients treated with PBM for ARD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 120 breast cancer patients treated with prophylactic PBM (<jats:italic>n<\/jats:italic>\u2009=\u200960, 2x\/week, 808\u2212905\u2009nm, 4\u2009J\/cm<jats:sup>2<\/jats:sup>) or placebo (<jats:italic>n<\/jats:italic>\u2009=\u200960) during conventional fractionation (CF) radiotherapy (RT) between April 2015 and June 2017 were retrospectively analyzed (TRANSDERMIS trial). During follow\u2010up (April 2015 to\u00a0May 2022), patients underwent a complete clinical evaluation every 6\u00a0months and blood analysis and mammography yearly in the first 5\u00a0years after the end of RT. The DFS, CFS, and OS were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a median follow\u2010up time of 66 months (range 4\u221281), there was no significant difference in DFS (73.7% vs. 98.3%, resp., <jats:italic>p<\/jats:italic>\u2009=\u20090.54), CFS (68.4% vs. 77.8%, resp., <jats:italic>p<\/jats:italic>\u2009=\u20090.79), and OS (87.9% vs. 98.3%, resp., <jats:italic>p<\/jats:italic>\u2009=\u20090.30) between the placebo and PBM group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This paper is the first to describe the results of a long\u2010term follow\u2010up in early\u2010stage breast cancer patients who underwent PBM for ARD. Results suggest that using PBM in breast cancer patients undergoing CF RT does not influence the locoregional recurrence, the development of new primary tumors, or OS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23608","type":"journal-article","created":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T19:43:05Z","timestamp":1664739785000},"page":"1261-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A long\u2010term follow\u2010up of early breast cancer patients treated with photobiomodulation during conventional fractionation radiotherapy in the prevention of acute radiation dermatitis"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-1581","authenticated-orcid":false,"given":"Jolien","family":"Robijns","sequence":"first","affiliation":[{"name":"Faculty of Medicine &amp; Life Sciences, Hasselt University Limburg Clinical Research Center  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-5196","authenticated-orcid":false,"given":"Joy","family":"Lodewijckx","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Life Sciences, Hasselt University Limburg Clinical Research Center  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0195-1655","authenticated-orcid":false,"given":"Marith\u00e9","family":"Claes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Life Sciences, Hasselt University Limburg Clinical Research Center  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lenaerts","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Life Sciences, Hasselt University Limburg Clinical Research Center  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-4318","authenticated-orcid":false,"given":"Leen","family":"Van Bever","sequence":"additional","affiliation":[{"name":"Limburg Oncology Center, Jessa Hospital\u2014Campus Virga Jesse  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0558-401X","authenticated-orcid":false,"given":"Stefan","family":"Claes","sequence":"additional","affiliation":[{"name":"Limburg Oncology Center, Jessa Hospital\u2014Campus Virga Jesse  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Pannekoeke","sequence":"additional","affiliation":[{"name":"Limburg Oncology Center, Jessa Hospital\u2014Campus Virga Jesse  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katleen","family":"Verboven","sequence":"additional","affiliation":[{"name":"Limburg Oncology Center, Jessa Hospital\u2014Campus Virga Jesse  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"No\u00e9","sequence":"additional","affiliation":[{"name":"Limburg Oncology Center, Jessa Hospital\u2014Campus Virga Jesse  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Maes","sequence":"additional","affiliation":[{"name":"Limburg Oncology Center, Jessa Hospital\u2014Campus Virga Jesse  Hasselt Belgium"},{"name":"Limburg Oncology Center, Ziekenhuis Oost\u2010Limburg  Genk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bulens","sequence":"additional","affiliation":[{"name":"Limburg Oncology Center, Jessa Hospital\u2014Campus Virga Jesse  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-4607","authenticated-orcid":false,"given":"Jeroen","family":"Mebis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Life Sciences, Hasselt University Limburg Clinical Research Center  Hasselt Belgium"},{"name":"Department of Medical Oncology Jessa Hospital  Hasselt Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz189"},{"key":"e_1_2_8_4_1","unstructured":"National Comprehensive Cancer Network. 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