{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:13:22Z","timestamp":1789442002495,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Microwave thermolysis (MWT) is an emerging treatment for axillary hyperhidrosis reducing both sweat and odor. No prior studies have investigated and compared the different available energy settings of the MWT\u00a0device. This study evaluated patient\u2010reported outcome measures (PROMs) for axillary hyperhidrosis and osmidrosis following MWT\u00a0treatment with two different energy levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty adults with axillary hyperhidrosis and osmidrosis reported sweat on Hyperhidrosis Disease Severity scale (HDSS: 1\u20134) and odor on Odor scale (OS: 1\u201310), respectively, supplemented by overall Dermatology Life Quality Index (DLQI: 0\u201330). This was a prospective, randomized, patient\u2010blinded and intraindividually controlled study with 3 months follow\u2010up (FU). Randomization comprised MWT\u00a0treatment of one axilla with a standard medium energy setting (energy level 3) and the contralateral axilla with a standard high energy setting (energy level 5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, patients reported substantial sweat and odor, negatively affecting their quality of life. At 3 months\u00a0FU, PROMs showed improved quality of life with significantly reduced odor and sweat. Overall DLQI was reduced from a median of 10 to 4, with a median 6.5\u2010point reduction (<jats:italic>p<\/jats:italic>\u2009=\u20090.0002). HDSS was reduced from a median of 4 to 2 on both sides, with a median reduction of 1 for medium energy level and 2 points for high energy level (<jats:italic>p<\/jats:italic>\u2009=\u20090.014). OS was reduced from a median of 8 to 3 for both energy levels, with a median reduction of 3.5 and 4.5 points for the medium and high energy level, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.017). Local skin reactions were mild and transient, but slightly more pronounced following treatment with the high energy level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MWT effectively improved patients\u2019 quality of life, axillary sweat, and odor 3 months after on baseline treatment. Treatment with the high energy level presented a subtle but significant increase of efficacy based on PROMs for both sweat and odor. Patients were willing to accept a higher amount of temporary local skin reactions from a higher energy setting when experiencing greater odor and sweat reduction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23610","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T05:23:14Z","timestamp":1665724994000},"page":"105-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Impact of microwave thermolysis energy levels on patient\u2010reported outcomes for axillary hyperhidrosis and osmidrosis"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-4458","authenticated-orcid":false,"given":"G. L.","family":"Grove","sequence":"first","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4272-4889","authenticated-orcid":false,"given":"K.","family":"Togsverd\u2010Bo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-1622","authenticated-orcid":false,"given":"J. F. B.","family":"Schwensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-6303","authenticated-orcid":false,"given":"N. W.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5961-9399","authenticated-orcid":false,"given":"C. V.","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-1319","authenticated-orcid":false,"given":"C.","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Gentofte Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-2035","authenticated-orcid":false,"given":"M.","family":"Haedersdal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02375.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23229"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.071"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.06.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2016.1248438"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12731"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.807114"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/DSU.0000000000000041"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2014.12.008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12448"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23073"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2021.1957115"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02250.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adengl.2017.03.029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1762837"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23412"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21142"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08832.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23621.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12425"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1342039"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:14:05Z","timestamp":1692587645000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,13]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/lsm.23610"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23610","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,13]]},"assertion":[{"value":"2022-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}