{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:42:22Z","timestamp":1791438142446,"version":"4.3.3"},"reference-count":91,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:00:00Z","timestamp":1665187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The skin aging exposome encompasses internal and external factors that contribute to clinical signs of facial aging. Aging skin can be characterized by distinctive features such as wrinkles, lentigines, elastosis, and roughness. Optical coherence tomography (OCT) is capable of noninvasively measuring skin characteristics. This study aimed to assess bilateral features using OCT to explore temporal skin changes among decades and potential changes in facial skin aging based on laterality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 97 subjects between 20 and 89 years old with Fitzpatrick skin types I to IV were enrolled. VivoSight, a Multi\u2010Beam OCT system intended to gather topographical and histological images of skin, was used to scan the area inferolateral to the lateral canthus, bilaterally. Investigators compared characteristics of skin roughness, attenuation coefficient\u00a0and blood flow across age groups and based on laterality to determine any differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only data from successful OCT scans were used. Seventy subjects, 10\u00a0from each specified decade, had successful bilateral scans and were thus included in the analysis. Chronological aging was characterized by significantly decreased dermal attenuation coefficient with increased age. Skin roughness measurements showed trends of increased roughness with age; however, no statistically significant changes were seen between groups. Qualitative differences amongst scans taken on right and left sides of the face showed no significance regarding roughness, density or blood flow at depths ranging from 0.05 to 0.5\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OCT is an effective method for evaluating changes in aging skin. Our results illustrate a decline in skin density with chronological age. Additionally, it was illustrated that structural change in the epidermis and dermis does occur, however on a microscopic scale, there are no significant differences based on laterality. OCT holds promise as a noninvasive technique for characterization of aging skin. Its utility and application in the clinical management and treatment of aged skin requires further research; however, the technology has potential to personalize therapies based on objective findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23611","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T09:34:33Z","timestamp":1665221673000},"page":"22-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation and characterization of facial skin aging using optical coherence tomography"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-0975","authenticated-orcid":false,"given":"Nicole R.","family":"Vingan","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3909-154X","authenticated-orcid":false,"given":"Shyon","family":"Parsa","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical School  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Barillas","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Culver","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Kenkel","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03160390039008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04991.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-89656-2_45"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2007.00415.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8041413"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.Epi-05-0456"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.09.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.1998.12"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0749-0690(05)70089-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12036"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32953-6_4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.394"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16010068"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30815-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199711133372003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/13813455.2015.1115525"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.028"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01708.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689717725755"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16638-0_3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.neo.7900071"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23219"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1957169"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12600"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","unstructured":"AmaralMM RaeleMP CalyJP SamadRE VieiraJr.ND FreitasAZ. Roughness measurement methodology according to DIN 4768 using optical coherence tomography (OCT).2009:73900Z.","DOI":"10.1117\/12.827748"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201500342"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.24.9.090901"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1364\/ao.32.006032"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051302"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1962.122"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)64040-0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12148.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00902.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212489"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0962-8924(00)01802-x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0962-8924(03)00057-6"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm809"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.108.3.1251"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0945-053x(99)00039-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14359"},{"key":"e_1_2_8_42_1","volume-title":"Fundamentals of anatomy & physiology","author":"Martini F","year":"2004"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117919"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1088.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/135206"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0738-081x(98)00042-x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910799"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12122.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-011-0918-1"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2005.04.004"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12092.x"},{"key":"e_1_2_8_52_1","first-page":"69","volume-title":"Reactive oxygen species (ROS) in living cells","author":"Xu H","year":"2017"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2014.983092"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0733-8635(05)70465-4"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12158"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12119"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/318586"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13033"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13999"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2004.00056.x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12407"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12294"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2001.70310.x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.01002.x"},{"issue":"1","key":"e_1_2_8_65_1","first-page":"103","article-title":"A three\u2010dimensional evaluation of human facial asymmetry","volume":"186","author":"Ferrario VF","year":"1995","journal-title":"J Anat"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2001.21872"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000717)93:2<143::aid-ajmg12>3.0.co;2-q"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0889-5406(93)70013-E"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1043\/0003-3219(1991)061<0043:Saiepf>2.0.Co;2"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1043\/0003-3219(1975)045<0125:Aothfs>2.0.Co;2"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1043\/0003-3219(1981)051<0214:Ioca>2.0.Co;2"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690010127031"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.032"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.05.026"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.062"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.09.021"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.1139"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.08073.x"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjw074"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.685563"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.1993.tb00562.x"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00378.x"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01752.x"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-021-02245-8"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjac108"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21147"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23233"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12859"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2008.00455.x"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.127.12.1806"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2001.70210.x"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12484"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/lsm.23611","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:13:43Z","timestamp":1692587623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,8]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/lsm.23611"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23611","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,8]]},"assertion":[{"value":"2022-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}