{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:29:40Z","timestamp":1762543780885,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Noninvasive cosmetic body contouring techniques are growing rapidly, and noninvasive lipolysis has been shown to have low pain, little downtime and produce consistent long\u2010term results. The objective of this study was to evaluate the safety and efficacy of a 1064\u2009nm diode laser combined with vacuum assisted PEMF and RF energies for noninvasive fat reduction of the abdomen and flanks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects received a series of three treatments 8 weeks apart, each consisting of a diode laser session, followed by vacuum assisted PEMF and RF. Before and after photographs were graded for overall fat reduction by three blinded evaluators. Ultrasound was used to measure changes in the thickness of adipose tissue. Subject satisfaction was assessed using the 5\u2010Point Likert Subject Satisfaction Scale and a subject questionnaire at 16 and 24\u2010week\u00a0follow\u2010up visits. Throughout each treatment, the subjects were given the Wong\u2010Baker Faces Pain Rating Scale (WBFS) to assess discomfort and pain of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010nine subjects (average age 48.6 years) from four clinical sites were enrolled. Evaluators identified the correct before and after images 73.1% of the time and images were graded an average score of 1.12\u00a0(SE 0.1) correlating to more than a \u201cslight change.\u201d Adipose tissue was reduced by 31.9% based on ultrasound measurements (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Subject satisfaction was high with an average satisfaction score of 7.8 (\u201csatisfied\u201d) out of 10. The overall pain over time on average was rated \u201churts little bit.\u201d\u00a0Ninety percent\u00a0of subjects reported either a mild, moderate, or significant improvement in their fat reduction and skin surface appearance. Almost 77%\u00a0(76.7%) of subjects reported that they would recommend the treatment to a friend. There were six reports of adverse events related to the device during the study that were all transient and resolved rapidly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant reduction of subcutaneous adipose tissue was measured after treatment with a combination of diode laser and vacuum assisted PEMF and RF. Treatment pain was low and tolerable, and subjects had high levels of satisfaction with the results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23654","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T15:49:10Z","timestamp":1680191350000},"page":"455-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical evaluation of the safety and efficacy of a 1064\u2009nm diode laser, and vacuum assisted pulsed\u00a0electromagnetic fields and multipolar radio frequency for noninvasive fat reduction of the abdomen and flanks"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9751-1987","authenticated-orcid":false,"given":"Karol A.","family":"Gutowski","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery University of Illinois and University of Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1425-6627","authenticated-orcid":false,"given":"Alison","family":"Kang","sequence":"additional","affiliation":[{"name":"Laser and Skin Surgery Center of Northern California Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-9340","authenticated-orcid":false,"given":"Suzanne L.","family":"Kilmer","sequence":"additional","affiliation":[{"name":"Laser and Skin Surgery Center of Northern California Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-1393","authenticated-orcid":false,"given":"R. Sonia","family":"Batra","sequence":"additional","affiliation":[{"name":"Batra Dermatology Santa Monica California USA"},{"name":"Department of Dermatology, Keck School of Medicine University of Southern California Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Vignan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8451-9031","authenticated-orcid":false,"given":"Jeffrey M.","family":"Kenkel","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Products\u2010Health E Stats\u2010prevalence of overweight obesity and extreme obesity among adults aged 20 and over: United States 1960\u20131962 Through 2017\u20132018 [Internet]. 2021 [cited 2022 Apr 28]. Available from:https:\/\/www.cdc.gov\/nchs\/data\/hestat\/obesity-adult-17-18\/obesity-adult.htm"},{"key":"e_1_2_7_3_1","unstructured":"Cosmetic surgery data bank statistics: American Society for Aesthetic Plastic Surgery; 2021 [Internet]. 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