{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:01:38Z","timestamp":1791270098345,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ablative fractional CO<jats:sub>2<\/jats:sub> laser (AFL) is an established first\u2010line energy\u2010based treatment for acne scars. Microneedle radiofrequency (MNRF) is an emerging treatment, also targeting the skin in fractions. No studies have so far compared AFL with MNRF for acne scars in a direct controlled, side\u2010by\u2010side comparison. In this study, we compared AFL and MNRF treatments for acne scars in a randomized split\u2010face trial with blinded response evaluation, objective measures, and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Method<\/jats:title><jats:p>Fifteen patients with moderate to severe acne scars were included. At baseline each patient had two similar test areas identified, these were randomized to receive a single treatment with either AFL or MNRF. Standardized multilayer techniques were applied with AFL and MNRF, first targeting the scar base, thereafter the entire scar area. Outcome measures included blinded evaluation of clinical improvement of scar texture (0\u201310 scale) at 1\u2010 and 3\u2010months follow\u2010up, local skin reactions (LSR), pain according to Visual Analogue Scale (VAS), skin integrity quantified by transepidermal water loss, and patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients completed the study with a median test area size of 24.6\u2009cm<jats:sup>2<\/jats:sup> (interquartile range\u00a0[IQR] 14.9\u201340.6). A single treatment with AFL or MNRF equally resulted in a median 1\u2010point texture improvement after 3 months follow\u2010up (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Best responders achieved up to a 3\u2010point improvement (<jats:italic>n<\/jats:italic>\u2009=\u20093 test areas, 10% of treatment areas). Erythema and loss of skin integrity was more intense after AFL compared with MNRF after 2\u20134 days (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Patients reported MNRF (VAS 7.0) to be significantly more painful than AFL (5.5) (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). Patients were generally satisfied with the overall outcome on a 10\u2010point scale at median 6 for both treatments (IQR 5\u20137).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AFL and MNRF treatments are equally effective at improving texture in skin with acne scars. AFL resulted in more pronounced LSRs whereas MNRF was more painful. Patients were generally satisfied with the overall outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23655","type":"journal-article","created":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T19:28:52Z","timestamp":1679254132000},"page":"335-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Fractional CO<sub>2<\/sub>\u2010laser versus microneedle radiofrequency for acne scars: A randomized, single treatment, split\u2010face trial"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1845-1224","authenticated-orcid":false,"given":"Kristoffer","family":"Hendel","sequence":"first","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-3634","authenticated-orcid":false,"given":"Katrine","family":"Karmisholt","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Hedelund","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aaarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-2035","authenticated-orcid":false,"given":"Merete","family":"Haedersdal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital Bispebjerg and Frederiksberg Copenhagen 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