{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:18:40Z","timestamp":1792639120433,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A fractional 1064\u2010nm picosecond laser is an efficient and safe treatment for atrophic acne scars. However, evidence of using a picosecond laser for atrophic posttraumatic and surgical scar therapy is lacking. This study aimed to evaluate the efficacy and safety of using a 1064\u2010nm picosecond laser with a microlens array (MLA) for the treatment of atrophic posttraumatic and surgical scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, intraindividual, single\u2010blinded, randomized split\u2010lesion\u2010controlled trial. Twenty\u2010five subjects with atrophic traumatic or surgical scars that existed for more than 1 year were enrolled. All atrophic scars were divided at the midline into two halves and randomly assigned to a treatment or control side. The treatment group was treated with a 1064\u2010nm picosecond laser with an MLA handpiece (spot size: 6\u20138\u2009mm, fluence: 1.0\u20131.2\u2009J\/cm<jats:sup>2<\/jats:sup>, repetition rate: 5\u2009Hz, three passes) for 3 monthly sessions. The scar volumes were objectively measured using a three\u2010dimensional (3D) photograph at baseline, 1 month after the first and second treatments, and 3 and 6 months after the final treatment. Subjective assessments were conducted by a blinded dermatologist and patients'\u00a0self\u2010assessment to evaluate improvements at 3 months after the final treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treated sides exhibited a significant volume reduction, with statistically significant improvements over the control group at 1 month after the first and second treatments and at 3 months after the final treatment (<jats:italic>p<\/jats:italic>\u2009=\u20090.024, 0.005, and 0.019, respectively). At 3 months after the final treatment, a blinded dermatologist correctly identified the treated side in 24 of 25 patients (96%). The patients rated the improvements as excellent (&gt;75%) and marked (50%\u201375%) in 36% and 48% of patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At 3 months, the 1064\u2010nm picosecond laser with a fractionated MLA can significantly reduce the posttraumatic and postsurgical atrophic scar volume in patients with Fitzpatrick skin types III\u2010V. Insufficient data preclude inferences regarding efficacy at 6 months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23675","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T21:42:15Z","timestamp":1683063735000},"page":"536-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and safety of fractional 1064\u2010nm picosecond laser for atrophic traumatic and surgical scars: A randomized, single\u2010blinded, split\u2010scar\u2010controlled study"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-4915","authenticated-orcid":false,"given":"Wareeporn","family":"Disphanurat","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Dermatology Thammasat University Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipathorn","family":"Charutanan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology Thammasat University Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradtana","family":"Sitthiwatthanawong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Dermatology Thammasat University Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worapop","family":"Suthiwartnarueput","sequence":"additional","affiliation":[{"name":"Department of Pathology and Forensic Medicine Thammasat University Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yacs.2021.01.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325646"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"624","article-title":"Treatment of atrophic scars with fractionated CO2 laser facilitating delivery of topically applied poly\u2010L\u2010lactic acid","volume":"40","author":"Rkein A","year":"2014","journal-title":"Dermatol\u00a0Surg"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.7761"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23201"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22606"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22297"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000306"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23244"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22540"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yacs.2018.02.007"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002572"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-019-02891-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16643"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15289"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12738"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yacs.2018.02.017"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22655"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003397"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1179-z"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03396-w"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14516"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700786"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002152"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2022.2100915"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3045"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23368"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23218"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2022.2055079"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23471"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22577"},{"issue":"11","key":"e_1_2_8_34_1","first-page":"1390","article-title":"A prospective split\u2010face study of the picosecond alexandrite laser with specialized lens array for facial photoaging in Chinese","volume":"15","author":"Ge Y","year":"2016","journal-title":"J\u00a0Drugs\u00a0Dermatol: JDD"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22752"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23390"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T21:24:31Z","timestamp":1692221071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/lsm.23675"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23675","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,2]]},"assertion":[{"value":"2023-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}