{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:12:44Z","timestamp":1785201164849,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The 730\u2009nm picosecond titanium sapphire laser is a novel laser that shows promising results in treating freckles. This study aimed to further investigate the efficacy and safety of the 730\u2009nm picosecond titanium sapphire laser for treating freckles in Asian patients compared with those of the 755\u2009nm picosecond alexandrite laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Each face of 86 participants was split into two parts and randomly assigned either one session of 730\u00a0or 755\u2009nm picosecond\u2010laser treatment each. Efficacy and safety were determined based on blinded visual evaluations and self\u2010reports at each follow\u2010up visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treatment outcomes of the 730\u2009nm picosecond laser for the treatment of freckles were comparable to those of the 755\u2009nm picosecond laser, with 68.99\u2009\u00b1\u20097.42% and 69.27\u2009\u00b1\u20097.75% clearance, respectively (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Participants achieved similar Global Aesthetic Improvement Scale scores (4.04\u2009\u00b1\u20090.31 vs. 4.02\u2009\u00b1\u20090.30, respectively [<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05]). Additionally, the 730\u2009nm picosecond laser was perceived to be less painful than the 755\u2009nm picosecond laser (4.69\u2009\u00b1\u20091.63 vs. 5.65\u2009\u00b1\u20091.80\u2009nm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 730\u2009nm picosecond laser is safe and effective for the treatment of freckles in Asian patients. Besides, the 730\u2009nm picosecond laser is less painful than the 755\u2009nm picosecond laser.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23679","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T14:10:50Z","timestamp":1685715050000},"page":"636-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of the efficacy and safety of a 730\u2009nm picosecond titanium sapphire laser and a 755\u2009nm picosecond alexandrite laser for the treatment of freckles in Asian patients: A two\u2010center randomized, split\u2010face, controlled trial"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-0366","authenticated-orcid":false,"given":"Mengli","family":"Zhang","sequence":"first","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6875-5811","authenticated-orcid":false,"given":"Huiying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Ge","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7469-4218","authenticated-orcid":false,"given":"Yin","family":"Yang","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Guo","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-4982","authenticated-orcid":false,"given":"Qiuju","family":"Wu","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zeng","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualing","family":"Shi","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Cai","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lin","sequence":"additional","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"},{"name":"Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology Chinese Academy of Medical Sciences &amp; 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