{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:24:09Z","timestamp":1792095849557,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether self\u2010applied photobiomodulation (PBM) therapy at home, following rotator cuff arthroscopic surgery (RCAS) can accelerate improvement in patient\u2010reported outcomes within the first 6 months postsurgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a prospective, double\u2010blind, sham\u2010controlled, randomized clinical trial (NCT04593342). Patients (<jats:italic>n<\/jats:italic>\u2009=\u200950, age 55\u2009\u00b1\u20097 years, male:female 29:21) who underwent primary RCAS were randomized to receive active (<jats:italic>n<\/jats:italic>\u2009=\u200922) or sham (<jats:italic>n<\/jats:italic>\u2009=\u200928) PBM devices (B\u2010Cure Laser Pro, Erica B\u2010Cure LASER Ltd., Haifa, Israel) in addition to standard care. Patients self\u2010applied the treatments (808\u2009nm, 15\u2009min, 16.5\u2009J\/cm<jats:sup>2<\/jats:sup>) at home for 3 months postsurgery. Evaluations were conducted before the surgery (baseline) and at 1\u20133 and 6 months post\u2010RCAS (FU\u20101M, FU\u20103M, FU\u20106M), and included Constant\u2013Murley score (CMS), range of motion (ROM), subjective pain by visual analogue scale (VAS), disability by QuickDASH, and quality of life (QOL) by SF\u201012. The difference from baseline to follow\u2010up (\u0394FU), %patients achieving minimal clinical important difference (MCID), and patient acceptable symptom score (PASS) were calculated. Comparisons were conducted with superiority 2\u2010sample <jats:italic>t<\/jats:italic> test and <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline values were not significantly different between groups. Both groups had similar improvements in CMS and ROM. However, compared to Sham, PBM significantly accelerated subjective pain reduction at 3 and 6 months (VAS mean\u2009\u00b1\u2009SD, PBM\u2010vs\u2010Sham: \u0394FU\u20103M 32\u2009\u00b1\u200933 vs. 16\u2009\u00b1\u200927, <jats:italic>p<\/jats:italic>\u2009=\u20090.040; \u0394FU\u20106M: 41\u2009\u00b1\u200936 vs. 23\u2009\u00b1\u200926, <jats:italic>p<\/jats:italic>\u2009=\u20090.038), with a significantly higher proportion of patients achieving MCID at 3 months (76% vs. 48%, <jats:italic>p<\/jats:italic>\u2009=\u20090.027) and PASS at 6 months (48% vs. 23%, <jats:italic>p<\/jats:italic>\u2009=\u20090.044). PBM also significantly accelerated improvement in functionality and QOL at 6 months (QuickDASH \u0394FU\u20106M: 30\u2009\u00b1\u200924 vs. 18\u2009\u00b1\u200914, <jats:italic>p<\/jats:italic>\u2009=\u20090.029; SF\u201012 physical component 6.8\u2009\u00b1\u200912.5 vs. 0.4\u2009\u00b1\u20098.6, <jats:italic>p<\/jats:italic>\u2009=\u20090.031; SF\u201012 mental component 8.5\u2009\u00b1\u20099.1 vs. 2.2\u2009\u00b1\u200912, <jats:italic>p<\/jats:italic>\u2009=\u20090.032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Self\u2010applied photobiomodulation following RCAS significantly accelerates decrease in pain and disability, and improves QOL. This nonpharmacologic add\u2010on therapeutic modality is easy to use and encourages active patient involvement. Its potential use in rehabilitation following other surgeries should be considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of evidence<\/jats:title><jats:p>Level I, high\u2010quality RCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23692","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T08:00:04Z","timestamp":1686211204000},"page":"662-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Photobiomodulation self\u2010treatment at home after rotator cuff arthroscopic repair accelerates improvement in pain, functionality, and quality of life:\u00a0A double\u2010blind, sham\u2010controlled, randomized clinical trial"],"prefix":"10.1002","volume":"55","author":[{"given":"Rabie","family":"Abufoul","sequence":"first","affiliation":[{"name":"Orthopedic Department The Holy Family Hospital Nazareth Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-8958","authenticated-orcid":false,"given":"Lilach","family":"Gavish","sequence":"additional","affiliation":[{"name":"Institute for Research in Military Medicine (IRMM), Faculty of Medicine The Hebrew University of Jerusalem and the Israel Defense Forces Medical Corps  Jerusalem Israel"},{"name":"The Saul and Joyce Brandman Hub for Cardiovascular Research and the Department of Medical Neurobiology, Institute for Medical Research (IMRIC), Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Haddad","sequence":"additional","affiliation":[{"name":"Orthopedic Department The Holy Family Hospital Nazareth Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"Surgery for rotator cuff tears","volume":"12","author":"Karjalainen TV","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2016.11.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04397-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520975426"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2020.12.219"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2019.04.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.9848"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781315364827-36"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0454-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.202000329"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61522-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0882-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2015-011036"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-031142"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973-9087.21.07236-1"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1757-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-1001-3"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pri.1606"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03584-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4387"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2021.0125"},{"key":"e_1_2_8_24_1","unstructured":"WALT.\u00a02010. 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