{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:42:16Z","timestamp":1790109736731,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Port wine birthmarks (PWBs) are vascular malformations affecting 0.3%\u20130.5% of newborns with the tendency to persist into adulthood without adequate treatment of the heterogenous ectatic vessels. This study compares treatment outcomes and parameters of the prior generation pulsed dye laser (PPDL) and the larger spot novel generation pulsed dye laser (NPDL) to establish whether a larger spot size laser provides greater clearance with fewer treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and sixty patients were treated with either the PPDL (80 patients) and NPDL (80 patients) with retrospective review of age, body site, laser treatment parameters, number of treatments, and improvement following laser therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients treated with PPDL were older on average than patients treated with NPDL (mean 24.8\u2009\u00b1\u200919.7 vs. mean 17.1\u00b1\u200919.3 years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The majority of lesions treated with PPDL were located on the face and neck, whereas truncal and extremity sites were more frequently treated with the NPDL. Use of NPDL was associated with a mean maximum spot size of 13.1\u2009mm and mean maximum fluence of 7.3\u2009J\/cm<jats:sup>2<\/jats:sup> with pulse durations of 0.45\u20133\u2009ms, whereas use of the PPDL was associated with a mean spot size of 10.8\u2009mm and mean maximum fluence of 8.8\u2009J\/cm<jats:sup>2<\/jats:sup> with pulse durations of 0.45\u20136\u2009ms. Fifty percent improvement was seen with 8.8 PPDL treatments compared to 4.3 NPDL treatments (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.01) with no significant difference in overall mean improvement between both devices at the chosen parameters. Multiple regression analysis showed that device type, not age or lesion location, was the only statistically significant independent variable to affect the endpoint of at least 50% improvement of the lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Use of the larger spot NPDL is associated with achieving 50% improvement with fewer treatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23693","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T10:00:57Z","timestamp":1686304857000},"page":"741-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Largest comparative analysis: Novel large spot size 595\u2009nm, high\u2010energy, pulsed dye laser reduces number of treatments for improvement of adult and pediatric port wine birthmarks"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-206X","authenticated-orcid":false,"given":"Pooja","family":"Sodha","sequence":"first","affiliation":[{"name":"Department of Dermatology George Washington University School of Medicine and Health Sciences Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan V.","family":"Wang","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Aboul\u2010Fettouh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic College of Medicine and Science Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Martin","sequence":"additional","affiliation":[{"name":"Central Dermatology Center Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy G.","family":"Geronemus","sequence":"additional","affiliation":[{"name":"Laser &amp; Skin Surgery Center of New York New York New York USA"},{"name":"The Ronald O Perelman Department of Dermatology New York University Langone Health New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Dermatology and Laser Surgery Center Houston Texas USA"},{"name":"Department of Dermatology, McGovern Medical School University of Texas Houston Texas USA"},{"name":"Department of Dermatology, Weill Cornell Medical College Houston Methodist Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.99100.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22819"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23309"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1102"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02219.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.5249"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.08.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12696885"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900110616"},{"issue":"11","key":"e_1_2_8_13_1","first-page":"1437","article-title":"JDD 2015\u2010ross\u2014role of beam spot size in heating targets at depth","volume":"14","author":"Ross VE","year":"2015","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_14_1","unstructured":"Food and Drug Administration. FDA drug safety communication: FDA approves label changes for use of general anesthetic and sedation drugs in young children. (2017). Accessed November 2 2022."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20529"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:05:43Z","timestamp":1694426743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/lsm.23693"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23693","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,9]]},"assertion":[{"value":"2022-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}