{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T16:49:05Z","timestamp":1747673345997,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary axillary hyperhidrosis (PAH) affects 1\u22125% of the world's population who has an unmet need for improved treatments. The heating of sweat glands with specific microwave therapy has shown promising results, yet, treatment with widely available devices such as long\u2010pulsed Neodymium Yttrium Aluminum Garnet (Nd:YAG) lasers, diode lasers or Intense Pulsed Light (IPL) may serve as pragmatic alternatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare sweat secretion of treated versus untreated contralateral control axilla 1\u22123 months after one session of Nd:YAG laser or IPL in patients with PAH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A within\u2010person randomized controlled trial. Patients were randomized to receive either one session of Nd:YAG laser or IPL in one axilla with the contra\u2010lateral serving as control. Sweat production was assessed by gravimetry, trans\u2010epidermal water loss, hyperhidrosis disease severity scale and dynamic optical coherence tomography. Mixed\u2010effects models were used to handle the within\u2010person design, containing both fixed effect factors (side, group, and subgroup), and random effects (patients), while also adjusting for the level at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20 patients were enrolled. At follow\u2010up 1\u22123 months after treatment, sweat secretion was not affected in the treated axilla when compared to the control axillae (0.01 [95%CI: \u22120.04 to 0.05]; <jats:italic>p<\/jats:italic>\u2009=\u20090.68). In the Nd:YAG subgroup (10 patients), least squares means for sweat secretion was 0.18\u2009mg\/5\u2009min in the treated versus 0.15\u2009mg\/5\u2009min in the control axilla, respectively, corresponding to a statistically insignificant mean difference of 0.02\u2009mg\/5\u2009min (95% CI: \u22120.06 to 0.11; <jats:italic>p<\/jats:italic>\u2009=\u20090.54). In the IPL subgroup (10 patients), sweat secretion was 0.06\u2009mg\/5\u2009min in the treated axilla versus 0.07\u2009mg\/5\u2009min in the control axilla with a statistically insignificant difference of \u20130.01 points (95% CI: \u22120.03 to 0.02; <jats:italic>p<\/jats:italic>\u2009=\u20090.46). Likewise, none of the secondary outcomes were significantly affected by treatment. However, both treatments appeared safe and well tolerated with no adverse effects reported at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One treatment with external 1064\u2009nm Nd:YAG laser or 640\u2009nm IPL at commercially available settings, failed to demonstrate clinical benefit in treating PAH, with narrow confidence intervals implying that this was not due to a type\u20102 error.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23697","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T09:50:56Z","timestamp":1686736256000},"page":"748-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Attempted treatment of primary axillary hyperhidrosis with one session of either Neodymium YAG laser or Intense Pulsed Light: A within patient randomized trial of treated versus untreated contralateral axilla"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8321-1633","authenticated-orcid":false,"given":"Elisabeth H.","family":"Taudorf","sequence":"first","affiliation":[{"name":"Department of Dermatology, Zealand University Hospital, Roskilde Hospital, Health Sciences Faculty University of Copenhagen Roskilde Denmark"},{"name":"Section for Biostatistics and Evidence\u2010Based Research, The Parker Institute Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Henning","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zealand University Hospital, Roskilde Hospital, Health Sciences Faculty University of Copenhagen Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zealand University Hospital, Roskilde Hospital, Health Sciences Faculty University of Copenhagen Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linnea","family":"Thorlacius","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zealand University Hospital, Roskilde Hospital, Health Sciences Faculty University of Copenhagen Roskilde Denmark"},{"name":"Section for Biostatistics and Evidence\u2010Based Research, The Parker Institute Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Christensen","sequence":"additional","affiliation":[{"name":"Section for Biostatistics and Evidence\u2010Based Research, The Parker Institute Bispebjerg and Frederiksberg Hospital Copenhagen Denmark"},{"name":"Department of Rheumatology, Institute of Clinical Research, Odense University Hospital University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zealand University Hospital, Roskilde Hospital, Health Sciences Faculty University of Copenhagen Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446786"},{"issue":"121","key":"e_1_2_7_3_1","first-page":"1","article-title":"The impact of hyperhidrosis on patients' daily life and quality of life: a qualitative investigation","volume":"15","author":"Kamudoni P","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"YuncuG TurkF OzturkG AtinkayaC. 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