{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:12:33Z","timestamp":1791828753255,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A new dual\u2010wavelength, high\u2010energy, solid\u2010state laser incorporating both 532 and 1064\u2009nm wavelengths was developed with cryogen spray cooling and the unique ability to deliver three types of pulse structures including single pulses of a specific pulse\u2010duration or pulses composed of a train of subpulses in the millisecond or microsecond domain with an intervening delay over the selected pulse\u2010duration. We investigate the efficacy of this laser using all three pulse structures and the 532\u2009nm wavelength for treating rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one subjects were enrolled in this IRB\u2010approved study. A total of up to three treatments were administered at monthly intervals. Each treatment consisted of a first pass tracing linear vessels with a 40\u2009ms pulse\u2010duration immediately followed by a second pass using a 5\u2009ms pulse, using all three available pulse structures. Assessment of cross\u2010polarized digital images by blinded physician observers compared baseline and 3\u2010month follow\u2010up images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blinded observers correctly identified the posttreatment images 89% of the time, in 17 of 19 subjects completing the study, with an average overall improvement rating of 39% after only three treatments. Side effects were limited to short\u2010term erythema and edema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that this new, variable\u2010pulse\u2010structure, dual wavelength, solid state, KTP laser with dynamic cooling is a safe and effective for treating rosacea.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23700","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T15:01:40Z","timestamp":1688742100000},"page":"734-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A new 532\u2009nm, variable\u2010pulse\u2010structure, dual\u2010wavelength, KTP laser incorporating cryogen spray cooling, effectively treats rosacea"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-7893","authenticated-orcid":false,"given":"Eric F.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Center 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