{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:18Z","timestamp":1740104178995,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Lip filler injections are one of the most popular procedures in esthetic dermatology. In this study, we used three\u2010dimensional colorimetric photography to assess lip color and optical coherence tomography\u2010angiography (OCT\u2010A), a noninvasive alternative to histopathology, to evaluate microcirculation after hyaluronic acid (HA) injection. The pain of the injection procedure was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An average of 0.85cc of the total volume of HA with lidocaine was injected into the upper and lower lip of eighteen young (&lt;30yo) and nine postmenopausal healthy women. OCT\u2010A, two\u2010dimensional, and three\u2010dimensional images were acquired immediately before (visit 1) and 15 days after injection (visit 2). Custom\u2010made software was used to analyze the imaging data to detect vessel morphology and redness changes. The Wong\u2010Baker FACES pain rating scale (0\u201310) was used to score the subject procedural pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For young and old subjects, three\u2010dimensional lip volume was greater than the injected volume. OCT\u2010A images of the lips showed higher vessel density and thickness, reaching statistical significance in the younger cohort. The overall trend of increased redness assessed by three\u2010dimensional colorimetric imaging and increased vascularity evaluated by OCT\u2010A imaging were similar. However, the correlation was not statistically significant for standard two\u2010dimensional digital photography. The average pain score after the first needle insertion and overall procedure were 2.9 and 3.5, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest an increased microvasculature network observed in OCT\u2010A images in young females. The increased blood vessel density and thickness observed by OCT\u2010A after HA lip filler injection is associated with increased lip redness and volume as assessed by colorimetric three\u2010dimensional photography; however, more research is needed to confirm these findings. This study presents OCT\u2010A as a novel noninvasive tool to investigate changes in lip microvascularity after HA filler injection and indicates that HA filler procedures may affect lip vascularity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23705","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T07:34:18Z","timestamp":1689147258000},"page":"838-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel assessment of lip redness and microcirculation using optical coherence tomography after dermal filler injection"],"prefix":"10.1002","volume":"55","author":[{"given":"Neera R.","family":"Nathan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Cutaneous Biology Research Center Massachusetts General Hospital Charlestown Massachusetts USA"},{"name":"Department of Dermatology Lahey Health and Medical Center Burlington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5396-4362","authenticated-orcid":false,"given":"Lais","family":"Lopes Almeida Gomes","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cutaneous Biology Research Center Massachusetts General Hospital Charlestown Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6461-4891","authenticated-orcid":false,"given":"Michael","family":"Wang\u2010Evers","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cutaneous Biology Research Center Massachusetts General Hospital Charlestown Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payal M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cutaneous Biology Research Center Massachusetts General Hospital Charlestown Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cutaneous Biology Research Center Massachusetts General Hospital Charlestown Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Manstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cutaneous Biology Research Center Massachusetts General Hospital Charlestown Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181811e2e"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003244"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002917"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001609"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.10.001315"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S63093"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1068\/p6730"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041669517717500"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101996"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12456"},{"key":"e_1_2_7_12_1","first-page":"475","volume-title":"Optical coherence tomography as a tool for real\u2010time visual feedback and biomechanical assessment of dermal filler injections: preliminary results in a pig skin model","author":"Singh M","year":"2016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92712-z"},{"issue":"2","key":"e_1_2_7_14_1","first-page":"S161","article-title":"A validated lip fullness grading scale","volume":"34","author":"Carruthers A","year":"2008","journal-title":"Dermatol Surg"},{"key":"e_1_2_7_15_1","unstructured":"AffairsR. Restylane\u00ae Kysse Instructions for use. Forth Worth TX;2020."},{"key":"e_1_2_7_16_1","unstructured":"TELESTO II Spectral Domain OCT System Operating Manual [Internet]. Munich;2016. Available from:www.thorlabs.com"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.402847"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.24.4.046005"},{"key":"e_1_2_7_19_1","unstructured":"Cherry Imaging Scientific System. 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