{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:07:12Z","timestamp":1785535632593,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapeutic dogma has been to treat acne scars with ablative fractional laser no less than 6 months after isotretinoin (ITN) cessation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and efficacy of fractional ablative CO<jats:sub>2<\/jats:sub> laser (FACL) in patients treated concurrently with ITN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective split\u2010face randomized control trial in patients treated with FACL concurrently with ITN versus patients treated with FACL 6 months post\u2010ITN treatment. Patients received 3 monthly sessions of FACL with concurrent ITN treatment on half of the face; the other side of the face received the same FACL treatment regimen 6 months post\u2010ITN cessation. Patients were followed for adverse effects up to 6 months post\u2010FACL treatment. Final cosmesis was scored using the Quantitative Global Acne Scarring Grading System (GASGS) by three independent dermatologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The GASGS of the concurrent ITN\u2010FACL treated side of the face was significantly lower than the side treated with delayed laser therapy (4.7\u2009\u00b1\u20092.5 vs. 7.7\u2009\u00b1\u20092.9, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>The laser's settings were standardized, and not adjusted per patient skin type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Per our prospective trial, concurrent treatment of FACL \u2010ITN is superior to delayed FACL treatment 6 months post\u2010ITN cessation.<\/jats:p><jats:p>Fractional ablative laser treatment is effective in improving acne scars, which persist despite isotretinoin therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23713","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T07:56:11Z","timestamp":1691567771000},"page":"54-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fractional ablative CO<sub>2<\/sub> laser and oral isotretinoin\u2014A prospective randomized controlled split\u2010face trial comparing concurrent versus delayed laser treatment for acne scars"],"prefix":"10.1002","volume":"56","author":[{"given":"Eyal","family":"Taleb","sequence":"first","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-2895","authenticated-orcid":false,"given":"Elisa S.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv 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