{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:53:29Z","timestamp":1790952809441,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Picosecond\u2010domain lasers have been fitted with fractionated optics for dermal remodeling. This study evaluates the safety and efficacy of a multiwavelength picosecond\u2010domain laser, using a 1064 nm multibeam lens array, for improving the appearance of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design\/Materials and Methods<\/jats:title><jats:p>Twenty adults with a clinical diagnosis of melasma were enrolled and received 4 monthly 1064\u2010nm, 450\u2009ps laser treatments delivered with a 10\u2009\u00d7\u200910 fractional array of 150\u2009\u00b5m microbeams. Cosmetic units with melasma were treated with fluences ranging from 1.7 to 2.9 mJ\/microbeam with a repetition rate of 6\u2009Hz. Treatment effect was evaluation of digital images by dermatologists blinded as to the treatment conditions, comparing baseline and 3\u2010 and 8\u2010month post\u2010treatment images. Modified melasma area and severity index (mMASI) scores were determined by the study investigator based on clinical photography. Subject self\u2010assessment of treatment effects was also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blinded reviewers correctly identified the post\u2010treatment image in 16 of the 20 image sets (80%). Ratings demonstrated statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) improvement on an 11\u2010point scale at both the 3\u2010 and 8\u2010month timepoints for a mean improvement of 3.7 point (range \u22128 to 10) or 37% improvement at the 3\u2010month follow\u2010up, and 2.7 (range \u22128 to 9) or 27% at the 8\u2010month follow\u2010up for all subjects. The average mMASI score showed highly significant reduction at both the 3\u2010 and 8\u2010month follow\u2010ups compared to baseline (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Most subjects (90%) were satisfied with the treatment outcome in melasma at both follow\u2010ups, which is consistent with the treatment outcome and mMASI scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The fractionated, picosecond\u2010domain, 1064\u2009nm laser is safe and effective for improving melasma and should be considered as an adjunct to topical treatment regimens and sun\u2010protection for management of melasma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23723","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:20:22Z","timestamp":1693916422000},"page":"801-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Melasma treatment with a 1064\u2009nm, picosecond\u2010domain laser with a fractionated multibeam lens array"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-7893","authenticated-orcid":false,"given":"Eric F.","family":"Bernstein","sequence":"first","affiliation":[{"name":"Main Line Center for Laser Surgery Ardmore Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa D.","family":"Basilavecchio","sequence":"additional","affiliation":[{"name":"Main Line Center for Laser Surgery Ardmore Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Wang","sequence":"additional","affiliation":[{"name":"SUNY Downstate Health Sciences University New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12783"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15242"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143063"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060824"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13803"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20956"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003635"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22263"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22735"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000653"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02001.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23474"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23615"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22518"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001521"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02178.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22100"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23312"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23382"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002612"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22734"},{"key":"e_1_2_5_24_1","first-page":"1077","article-title":"Treatment of photoaging with a Dual\u2010Wavelength, 532 nm and 1,064 nm picosecond\u2010domain laser producing a fractionated treatment beam using a holographic optic","volume":"16","author":"Bernstein EF","year":"2017","journal-title":"J Drug Dermatol"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.051"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23624"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20329"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T11:11:31Z","timestamp":1698059491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,5]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/lsm.23723"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23723","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,5]]},"assertion":[{"value":"2023-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}