{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:57:36Z","timestamp":1773280656424,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61575221"],"award-info":[{"award-number":["61575221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the wound healing of rabbit cornea following infrared laser irradiations at the wavelengths of 1.319\u00a0and 10.6\u2009\u03bcm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twelve New Zealand rabbits were selected to establish a corneal injury model. The right and left eyes were irradiated with a neodymium\u2010doped yttrium aluminum garnet\u00a0laser at the wavelength of 1.319\u2009\u03bcm (140\u2009J\/cm<jats:sup>2<\/jats:sup>) for 0.7\u2009s and a CO<jats:sub>2<\/jats:sub> laser at the wavelength of 10.6\u2009\u03bcm (5.94\u2009J\/cm<jats:sup>2<\/jats:sup>) for 0.14\u2009s, respectively. The incident spot diameter was 3\u2009mm. Optical coherence tomography (OCT) was used to monitor injuries at 0\u2009h, 0.5\u2009h, 1\u2009h, 3\u2009h, 6\u2009h, 12\u2009h, 18\u2009h, 24\u2009h, 30\u2009h, 36\u2009h, 42\u2009h, 48\u2009h, 54\u2009h, 60\u2009h, 66\u2009h, 3\u2009d, 7\u2009d, 14\u2009d, 28\u2009d, 3\u2009m, and 6\u2009m postexposure. Meanwhile, slit\u2010lamp microscopy and histopathology were performed at 6\u2009h, 24\u2009h, 3\u2009d, 7\u2009d, 14\u2009d, 28\u2009d, 3\u2009m, and 6\u2009m postexposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the two types of infrared laser injuries, distinct white circular lesions on the corneal surface were directly observed. Deeper corneal injury, more severe edema, and faster migration of new epithelium were found for the wavelength of 1.319\u2009\u03bcm, compared to the wavelength of 10.6\u2009\u03bcm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OCT combined with histopathology and slit\u2010lamp microscopy can clearly observe the dynamic process of corneal wound healing after infrared laser irradiation. The damage characteristics for the two different wavelengths were visibly different, but the whole wound healing process was\u00a0similar. The obtained results may provide references for the diagnosis, treatment, and evaluation of laser\u2010induced damages.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23749","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T05:24:15Z","timestamp":1702877055000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Corneal wound healing following infrared laser irradiation at the wavelengths of 1.319\u00a0and 10.6\u2009\u03bcm"],"prefix":"10.1002","volume":"56","author":[{"given":"Congling","family":"Zhou","sequence":"first","affiliation":[{"name":"Beijing Institute of Radiation Medicine Beijing China"},{"name":"School of Life Sciences Hebei University Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixue","family":"Yin","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine Beijing China"},{"name":"Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarui","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziqi","family":"Ren","sequence":"additional","affiliation":[{"name":"School of Management Hebei University Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-9597","authenticated-orcid":false,"given":"Luguang","family":"Jiao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Life Sciences Hebei University Baoding China"},{"name":"College of Osteopathic Medicine of the Pacific Western University of Health Sciences Pomona California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-868X","authenticated-orcid":false,"given":"Zaifu","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Radiation Medicine Beijing China"},{"name":"School of Life Sciences Hebei University Baoding China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004397-199903920-00003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(99)00436-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.11.1470"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080100106053"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31243-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31818c2c89"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2017.07.034"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2014.11.046"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.7.002016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.8.002745"},{"issue":"8","key":"e_1_2_8_12_1","first-page":"787","article-title":"Corneal injury threshold in rabbits for the 1540 nm infrared laser","volume":"73","author":"Clarke TF","year":"2002","journal-title":"Aviat Space Environ Med"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000248146.90949.0d"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2822371"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900120605"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-200310000-00005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.24.003080"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1793545821500048"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-200101000-00008"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21052"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(03)90017-X"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6120115"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-198901000-00008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.1.015011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2015.04.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.109210"},{"issue":"4","key":"e_1_2_8_27_1","first-page":"464","article-title":"Epithelial wound closure in the rabbit cornea. 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