{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:19:38Z","timestamp":1770153578509,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris (AV) is a prevalent skin condition known for its potential to cause scarring and psychological distress, often leading to diminished self\u2010esteem. While topical and oral treatments are commonly prescribed, some patients experience treatment failure, adverse effects, or contraindications to conventional therapies. In response to these challenges, laser and energy\u2010based device therapies have emerged as promising alternatives for individuals who fall into these categories, showing considerable potential in the treatment of AV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the long\u2010term efficacy and safety of a nonablative monopolar radiofrequency (NMRF) in treatment of moderate to severe AV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four patients with moderate to severe AV underwent a series of two NMRF treatment sessions, spaced 4 weeks apart. To evaluate treatment outcomes, live in\u2010person lesion counts and measurements of pore size and volume, and sebum production were quantified using Antera\u00ae 3D imaging system, and Sebumeter\u00ae, respectively. Patients' self\u2010assessment data regarding degree of improvement and facial oiliness were gathered. Dermatology life quality index (DLQI) questionnaire was utilized to assess the impact of AV on their quality of life. All objective and subjective evaluations were conducted at the baseline, 1 month after the first treatment, and during follow\u2010up visits 1, 3, and 6 months after the last treatment sessions. Adverse effects were also recorded during each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty out of the 24 subjects completed the study protocol. The mean inflammatory lesion counts significantly reduced by 42.86% and 45.71% from the baseline at 3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.027) and 6 months (<jats:italic>p<\/jats:italic>\u2009=\u20090.032) after the second treatment. Sebum excretion likewise significantly decreased from baseline by 11.62% (<jats:italic>p<\/jats:italic>\u2009=\u20090.012), 13.37% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and 21.51% (<jats:italic>p<\/jats:italic>\u2009=\u20090.004), 1 month after the first treatment, 1 and 6 months after the second treatment, respectively. The pore volume continued to decrease by 35% (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and 41.5% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) at 1 and 6 months following the final treatment, respectively. The DLQI significantly decreased from 10.00 (interquartile range [IQR]: 6.50\u221215.00) to 2.00 (IQR: 1.00\u22124.75), corresponding to 80% improvement of the index, 1 month after the last treatment and was sustained up to the last follow\u2010up visit. Patients' self\u2010assessments on degree of improvement and facial oiliness also significantly improved following NMRF treatments. The treatments were well\u2010tolerated without significant adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NMRF appears to be an effective and safe treatment for inflammatory AV, with therapeutic outcomes persisting up to 6 months after two treatment sessions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23757","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T07:39:15Z","timestamp":1705304355000},"page":"133-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term efficacy and safety of nonablative monopolar radiofrequency in the treatment of moderate to severe acne vulgaris"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-7963","authenticated-orcid":false,"given":"Woraphong","family":"Manuskiatti","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supisara","family":"Wongdama","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noldtawat","family":"Viriyaskultorn","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne Bernadeth","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanokvalai","family":"Kulthanan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj 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