{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:35:40Z","timestamp":1788428140496,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the clinical efficacy and safety of fractional microneedle radiofrequency (FMR) for facial atrophic acne scars in a real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of patients with atrophic acne scars who had received FMR therapy from February 2018 to August 2022 were retrospectively analyzed. The improvement of atrophic acne scars was assessed using the ECCA Grading Scale (\u00e9chelle d'\u00e9valuation clinique des cicatrices d'acn\u00e9), Global Aesthetic Improvement Scale (GAIS), and modified Manchester Scar Scale (mMSS). Adverse reactions during FMR treatment were also recorded. Univariate and multivariate logistic regression analyses were performed to evaluate the efficacy and safety of FMR for atrophic acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 126 patients with facial atrophic acne scars were included. A total of 590 FMR treatment sessions were accomplished, with each of 82 patients receiving 4 or more treatment sessions, and 1 receiving a maximum of 14 sessions. All patients showed improvement in symptoms after FMR treatment, with moderate to significant improvement (ECCA score reduction of 26%\u2013100%) in 92 (73.0%) patients. As the number of treatment sessions increased, the ECCA score gradually decreased from an average of 85.6 before to 35.0 after FMR. The average scores for distortion, color, and visual analogue scale (VAS) of mMSS all showed certain reductions. The change in GAIS score indicated improvement after treatment, with minimal improvement in 16 patients (12.7%), good improvement in 57 patients (45.2%), significant improvement in 45 patients (35.7%), and optimal improvement in 8 patients (6.4%). The univariate and multivariate logistic regression analyses revealed that the long pulse width and the number of FMR treatment sessions were positively associated with clinical efficacy. Compared to the short pulse\u2010width group (200\u2009ms), the longer pulse\u2010width group (300\u2009ms) (odds ratio [OR]\u2009=\u20098.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and the even longer pulse\u2010width group (400\u2013500\u2009ms) (OR\u2009=\u200952.6, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) demonstrated stronger efficacies. Patients who received more than three treatment sessions had better outcomes\u00a0compared to those who received three or fewer treatment sessions (OR\u2009=\u20094.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.036). All patients experienced posttreatment transient erythema, but no crusting, infection, or blister. Six cases developed grid\u2010like erythema around 1 month posttreatment\u00a0and one case experienced hyperpigmentation, both of which resolved within 1\u20133 months after appropriate management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FMR is a safe and effective treatment modality for improving facial atrophic acne scars, and the number of FMR treatment sessions and pulse width are associated with clinical efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23759","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:15:35Z","timestamp":1706501735000},"page":"150-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of fractional microneedle radiofrequency for atrophic acne scars: A real\u2010world clinical study of 126 patients"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9236-641X","authenticated-orcid":false,"given":"Ziwei","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"},{"name":"Department of Cosmetic Dermatology Dr. Zhou's Cosmetic Dermatological Clinic Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Dermatology Dr. Zhou's Cosmetic Dermatological Clinic Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Dermatology Dr. Zhou's Cosmetic Dermatological Clinic Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nantong Third People's Hospital Affiliated to Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanchao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Dermatology Dr. Zhou's Cosmetic Dermatological Clinic Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingrong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113451"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01200.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05749.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23484"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0358-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.264"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14868"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0004-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2016.1228981"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20687"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13396"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23655"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14071"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15454"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/picr.picr_217_21"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.13464\/j.scuxbyxb.2010.05.001"},{"issue":"8","key":"e_1_2_8_18_1","first-page":"731","article-title":"Rhytides, laxity and photoaging treated with a combination of radiofrequency, diode laser, and pulsed light and assessed with a comprehensive grading scale","volume":"5","author":"Alexiades\u2010Armenakas M","year":"2006","journal-title":"J. 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