{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:54:02Z","timestamp":1790952842887,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Pulsed laser treatment of melasma has shown some promising results. To compare the effectiveness and safety of 755\u2010nm picosecond alexandrite laser (PSAL) fitted with diffractive lens array (DLA) versus 1064\u2010nm Q\u2010switched neodynimum:yttrium aluminum garnet laser (QSNYL) for the treatment of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a randomized, split face controlled, 2\u2010year follow\u2010up study. Each face was divided into two parts, each side receiving three treatments with either PSAL or QSNYL at 1 month intervals. Modified Melasma Area Severity Index scores (mMASI), pain scores, patient satisfaction and adverse events were recorded. In vivo reflectance confocal microscopy (RCM) images were acquired.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty subjects were enrolled and three dropped out. At 6 months, mMASI scores were significantly lower than baseline for QSNYL sides (<jats:italic>p<\/jats:italic>\u2009=\u20090.022), with no statistically significant difference between PSAL sides before and after treatment, PSAL sides versus QSNYL sides, or patient satisfaction scores. QSNYL treatment was associated with less pain (<jats:italic>p<\/jats:italic>\u2009=\u20090.014). No serious adverse events were reported. In the PSAL sides RCM showed a large number of dendritic melanocytes infiltrated in the dermis at 2 weeks and 4 weeks after treatment. Ten patients (58.82%) reported recurrence or exacerbation at 2\u2010year follow\u2010up with no statistically significant difference between the two lasers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>QSNYL demonstrated short term clinical efficacy for melasma, but did not provide any additional benefit compared to PSAL with DLA. QSNYL was associated with less pain. There was a high recurrence rate at 2\u2010year follow\u2010up. RCM allowed the detection of cellular changes in melasma lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23763","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T04:14:37Z","timestamp":1706501677000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of 755\u2010nm picosecond alexandrite laser versus 1064\u2010nm Q\u2010switched Nd:YAG laser for melasma: A randomized, split\u2010face controlled, 2\u2010year follow\u2010up study"],"prefix":"10.1002","volume":"56","author":[{"given":"Yanjun","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Dermatology, West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital Sichuan University Chengdu 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