{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:38:01Z","timestamp":1788201481231,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Subcutaneous mastectomy is a crucial component of gender affirmation therapy for transgender men (TM), but the scars that result from this procedure can frequently impair their quality of life. This study aimed to assess the efficacy and safety of 1064\u2010nm fractional picosecond laser (FxPico) treatment for hypertrophic and atrophic postmastectomy scars in TM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two patients with a total of 35 pairs of bilateral symmetric mastectomy scars were enrolled. One of each pair of symmetric scars was randomly assigned to receive four FxPico treatments at 4\u2010week intervals. All scars were evaluated using the modified Vancouver Scar Scale (mVSS) and three\u2010dimensional imaging for scar roughness, melanin index, and hemoglobin index before each treatment session and at 1, 3, and 6 months following the last treatment. Additionally, participant\u2010rated scar satisfaction (PSS) and scar improvement (Global Assessment Score, GAS), as well as adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 6\u2010month follow\u2010up period after the end of laser treatment sessions, the treated scars showed significant reductions in the mVSS compared to the untreated controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), whereas the melanin index and hemoglobin index were not significantly different. Subgroup analysis of hypertrophic scars demonstrated statistically significant reductions in mVSS at 1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and 3 months (<jats:italic>p<\/jats:italic>\u2009=\u20090.041) after the end of laser treatments. PSS was significantly higher on the laser\u2010treated scars than the controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.008), and a participant\u2010rated GAS of 2.95\u2009\u00b1\u20090.65 was found. There were no serious adverse events reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>1064\u2010nm FxPico could be utilized to treat mastectomy scars among TM, particularly the hypertrophic type.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23775","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T10:20:28Z","timestamp":1709547628000},"page":"337-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of 1064\u2010nm fractional picosecond laser for the treatment of postmastectomy scars in transgender men: A randomized controlled trial"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-8790","authenticated-orcid":false,"given":"Suthinee","family":"Rutnin","sequence":"first","affiliation":[{"name":"Division of Dermatology Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanat","family":"Yongpisarn","sequence":"additional","affiliation":[{"name":"Division of Dermatology Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawara","family":"Sakpuwadol","sequence":"additional","affiliation":[{"name":"Division of Dermatology Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amornrut","family":"Namasondhi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherrin","family":"Pomsoong","sequence":"additional","affiliation":[{"name":"Division of Dermatology Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teerapong","family":"Rattananukrom","sequence":"additional","affiliation":[{"name":"Division of Dermatology 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