{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:01:45Z","timestamp":1789077705037,"version":"build-2803163510"},"reference-count":95,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Port wine birthmark (PWB) is a congenital vascular malformation of the skin. Pulsed dye laser (PDL) is the \u201cgold standard\u201d for the treatment of PWB globally. Hematoporphyrin monomethyl ether (HMME or hemoporfin)\u2010mediated photodynamic therapy (HMME\u2013PDT) has emerged as the first choice for PWB treatment, particularly for young children, in many major hospitals in China during the past several decades.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate whether HMME\u2013PDT is superior to PDL by comparing the clinical efficacies of both modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>PubMed records were searched for all relevant studies of PWB treatment using PDL (1988\u22122023) or HMME\u2013PDT (2007\u22122023). Patient characteristics and clinical efficacies were extracted. Studies with a quartile percentage clearance or similar scale were included. A mean color clearance index (CI) per study was calculated and compared among groups. An overall CI (C<jats:sub>0<\/jats:sub>), with data weighted by cohort size, was used to evaluate the final efficacy for each modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 18 HMME\u2013PDT studies with 3910 patients in China were eligible for inclusion in this analysis. Similarly, 40 PDL studies with 5094 patients from nine different countries were eligible for inclusion in this analysis. Over 58% of patients in the HMME\u2010PDT studies were minors (&lt;18 years old). A significant portion (21.3%) were young children (&lt;3 years old). Similarly, 33.2% of patients in the PDL studies were minors. A small proportion (9.3%) was young children. The overall clearance rates for PDL were slightly, but not significantly, higher than those for HMME\u2013PDT in cohorts with patients of all ages (C<jats:sub>0<\/jats:sub>, 0.54 vs. 0.48, <jats:italic>p<\/jats:italic>\u2009=\u20090.733), subpopulations with only minors (C<jats:sub>0<\/jats:sub>, 0.54 vs. 0.46, <jats:italic>p<\/jats:italic>\u2009=\u20090.714), and young children (C<jats:sub>0<\/jats:sub>, 0.67 vs. 0.50, <jats:italic>p<\/jats:italic>\u2009=\u20090.081). Regrettably, there was a lack of long\u2010term data on follow\u2010up evaluations for efficacy and impact of HMME\u2010PDT on young children in general, and central nervous system development in particular, because their blood\u2010brain barriers have a greater permeability as compared to adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PDL shows overall albeit insignificantly higher clearance rates than HMME\u2010PDT in patients of all ages; particularly statistical significance is nearly achieved in young children. Collectively, current evidence is insufficient to support HMME\u2013PDT as the first choice of treatment of PWBs in young children given: (1) overall inferior efficacy as compared to PDL; (2) risk of off\u2010target exposure to meningeal vasculature during the procedure; (3) administration of steriods for mitigation of side effects; \u2010and (4) lack of long\u2010term data on the potential impact of HMME on central nervous system development in young children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23779","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T12:38:57Z","timestamp":1710938337000},"page":"321-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Current clinical evidence is insufficient to support HMME\u2013PDT as the first choice of treatment for young children with port wine 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology XiJing Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, School of Medicine University of South Carolina Columbia South Carolina USA"},{"name":"Division of Plastic Surgery Prisma Health Medical Group Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold I.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, School of Medicine University of South Carolina Columbia South Carolina USA"},{"name":"Division of Plastic Surgery Prisma Health Medical Group Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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