{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:43:10Z","timestamp":1773675790996,"version":"3.50.1"},"reference-count":87,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Knowledge of the physical effects of pulsed dye laser (PDL) treatment of psoriatic lesions is essential in unraveling the remedial mechanisms of this treatment and hence also in maximizing in its disease\u2010modifying potential. Therefore, the main objective of this study was to provide estimates of these physical effects (for laser wavelengths of 585\u00a0and 595\u2009nm), with the aim of identifying pathogenic processes that may be affected by these conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We modeled the laser light propagation and subsequent photothermal heating by numerically solving the transient diffusion and heat equations simultaneously. To this end, we used the finite element method in conjunction with an image\u2010derived psoriatic lesion morphology (which was defined by segmenting blood vessels from a confocal microscopy image of a fluorescently labeled section of a 3\u2009mm punch biopsy of a psoriatic lesion). The resulting predictions of the generated temperature field within the lesion were then used to assess the possibility of stalling or arresting some suspected pathogenic processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to our results, it is conceivable that perivascular nerves are thermally denatured, as almost all locations that reach 60\u00b0C were found to be within 18\u2009\u00b5m (at 585\u2009nm) and 11\u2009\u00b5m (at 595\u2009nm) of a blood vessel wall. Furthermore, activation of TRPV1 and TRPV2 channels in perivascular neuronal and immune cells is highly likely, since a critical temperature of 43\u00b0C is generated at locations within up to 350\u2009\u00b5m of a vessel wall (at both wavelengths) and sustained for up to 700\u2009ms (at 585\u2009nm) and 40\u2009ms (at 595\u2009nm), while a critical temperature of 52\u00b0C is reached by locations within 80\u2009\u00b5m (at 585\u2009nm) and 30\u2009\u00b5m (at 595\u2009nm) of a vessel wall and sustained for up to 100\u2009 ms (at 585\u2009nm) and 30\u2009ms (at 595\u2009nm). Finally, we found that the blood vessel coagulation\u2010inducing temperature of 70\u00b0C is sustained in the vascular epithelium for up to 19\u00a0and 5\u2009ms at 585\u00a0and 595\u2009nm, respectively, rendering partial or total loss of vascular functionality a distinct possibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presented approach constitutes a useful tool to provide realistic estimates of the photothermal effects of PDL\u00a0treatment of psoriatic plaques (as well as other selective photothermolysis\u2010based treatments), yielding information that is essential in guiding future experimental studies toward\u00a0unraveling the remedial mechanisms of these treatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23781","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T07:28:35Z","timestamp":1712302115000},"page":"508-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modeling pulsed dye laser treatment of psoriatic plaques by combining numerical methods and image\u2010derived lesion morphologies"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-8552","authenticated-orcid":false,"given":"Leah S.","family":"Wilk","sequence":"first","affiliation":[{"name":"Amsterdam UMC, location University of Amsterdam Biomedical Engineering and Physics Amsterdam The Netherlands"},{"name":"Co van Ledden Hulsebosch Center University of Amsterdam Amsterdam The Netherlands"},{"name":"Amsterdam Public Health, Methodology Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-7742","authenticated-orcid":false,"given":"Meagan","family":"Doppegieter","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location University of Amsterdam Biomedical Engineering and Physics Amsterdam The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Microcirculation Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"van der Beek","sequence":"additional","affiliation":[{"name":"ZBC MultiCare Independent Treatment Center for Dermatology Hilversum The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ton G.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location University of Amsterdam Biomedical Engineering and Physics Amsterdam The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences Heart Failure and Arrythmias Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam Imaging and Biomarkers Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice C. G.","family":"Aalders","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location University of Amsterdam Biomedical Engineering and Physics Amsterdam The Netherlands"},{"name":"Co van Ledden Hulsebosch Center University of Amsterdam Amsterdam The Netherlands"},{"name":"Amsterdam Public Health, Methodology Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1590"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.768"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23896"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1593-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.10.025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1398393"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17625"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0176-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70406-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2018.07.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04474.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.54.165"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90498-3"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/02844319309079798"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06827.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.072"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1996)19:3<331::AID-LSM8>3.0.CO;2-T"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900010310"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02133615"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00669.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mla.2010.03.002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155598433368"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.60"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1997.tb01542.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1169-1"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00629.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/0265673031000065042"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1114\/B:ABME.0000042226.97347.de"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01821-5"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.411898"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/2151237X.2007.10129236"},{"key":"e_1_2_10_34_1","volume-title":"Digital image processing using MATLAB","author":"Gonzalez RC","year":"2004"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.00506"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.28.002331"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900160204"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-8831-4"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199805000-00003"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511841606"},{"key":"e_1_2_10_41_1","volume-title":"Human anatomy & physiology","author":"Marieb EN","year":"2008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.351"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/18906"},{"issue":"1","key":"e_1_2_10_44_1","first-page":"11","article-title":"Thermal profiles of blood vessels heated by a laser","volume":"12","author":"Pickering JW","year":"1989","journal-title":"Australas Phys Eng Sci Med"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14816"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0183-7"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12035"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900040410"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2010.01.003"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.12.029"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70201-6"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.4324\/9781315152837-8"},{"issue":"3","key":"e_1_2_10_53_1","first-page":"129","article-title":"Pulsed dye laser for the treatment of nail psoriasis","volume":"92","author":"Yin N","year":"2013","journal-title":"Cutis"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36372"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1088\/1555-6611\/aa8cdb"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12519832"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20104"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.021"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04280.x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12606996"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-1000-4"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0068"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1615\/critrevbiomedeng.2015012486"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80254-9"},{"key":"e_1_2_10_65_1","first-page":"321","volume-title":"Optical\u2010thermal response of laser\u2010irradiated tissue","author":"Barton JK","year":"2011"},{"key":"e_1_2_10_66_1","first-page":"859","volume-title":"Optical\u2010thermal response of laser\u2010irradiated tissue","author":"Majaron B","year":"2011"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/43\/5\/017"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/15368378.2020.1741383"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheatmasstransfer.2015.06.077"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheatmasstransfer.2013.09.032"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cam.2005.07.022"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbe.2018.01.004"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18123"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198906000-00001"},{"issue":"10","key":"e_1_2_10_75_1","first-page":"400","article-title":"The effect of aging on conductive heat exchange in the skin at two environmental temperatures","volume":"12","author":"Petrofsky JS","year":"2006","journal-title":"Med Sci Monit"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1090\/gsm\/019"},{"key":"e_1_2_10_77_1","first-page":"431","article-title":"A form of heat\u2010conduction equations which eliminates the paradox of instantaneous propagation","volume":"247","author":"Cattaneo C","year":"1958","journal-title":"Comptes Rendus"},{"key":"e_1_2_10_78_1","first-page":"3154","article-title":"Les paradoxes de la theorie continue de l'equation de la chaleur","volume":"246","author":"Vernotte P","year":"1958","journal-title":"Comptes Rendus"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.3124646"},{"issue":"5","key":"e_1_2_10_80_1","first-page":"695","article-title":"Studies of thermal injury: II. the relative importance of time and surface temperature in the causation of cutaneous burns","volume":"23","author":"Moritz AR","year":"1947","journal-title":"Am J Pathol"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2013.786140"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-02704-1"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730500307298"},{"key":"e_1_2_10_84_1","first-page":"487","volume-title":"Optical\u2010Thermal response of laser\u2010irradiated tissue","author":"Thomsen S","year":"2011"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.042"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2023.2241691"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12106"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00290-0"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T04:45:29Z","timestamp":1718513129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,5]]},"references-count":87,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/lsm.23781"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23781","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,5]]},"assertion":[{"value":"2023-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}