{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:21:26Z","timestamp":1791217286562,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory condition characterized by painful nodules, draining tunnels, and fibrotic scarring in intertriginous, hair\u2010bearing areas. The pathogenesis involves follicular occlusion and subsequent rupture, leading to uncontrolled inflammation. Treatment options for HS are limited and lack universal effectiveness. Laser hair removal (LHR) has been explored as a potential treatment; however, the efficacy and appropriate laser modalities remain unclear. This systematic review examined the efficacy and adverse effects of LHR in HS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature search was conducted from inception to September 2023 in Ovid MEDLINE, Ovid Embase, and The Cochrane Library (Wiley) with predefined inclusion and exclusion criteria, and a meta\u2010analysis was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten studies were selected (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009227 total patients) and included six randomized controlled trials, two nonrandomized experimental studies, and two case series. Various laser modalities, including long\u2010pulsed neodymium\u2010doped yttrium aluminum garnet (Nd:YAG) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009115), intense pulsed light (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918), Alexandrite (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200954), intralesional 1064\u2009nm diode (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), and combined fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      and long\u2010pulsed Nd:YAG laser (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), consistently demonstrated significant improvement in HS disease severity, irrespective of the disease scoring method used. Minimal adverse effects (primarily mild pain and erythema) were reported. A meta\u2010analysis of three studies utilizing long\u2010pulsed Nd:YAG laser demonstrated a standardized mean difference in disease severity of \u22121.68 (95% confidence interval: \u22122.99; \u22120.37), favoring treatment with LHR for HS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hair follicles are key in HS pathogenesis and all included studies showed a significant improvement in HS disease severity after LHR regardless of the laser device used, likely related to hair follicle unit destruction. HS is a complex and heterogenous condition, and multiple disease scoring methods complicate outcome comparisons across studies. However, LHR, utilizing various techniques, is an effective treatment option for HS with minimal adverse effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/lsm.23796","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T02:59:31Z","timestamp":1716260371000},"page":"425-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of laser hair removal in hidradenitis suppurativa: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-0610","authenticated-orcid":false,"suffix":"III","given":"William D.","family":"Shipman","sequence":"first","affiliation":[{"name":"Department of Dermatology Yale University New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica N.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of 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