{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:18:22Z","timestamp":1790068702058,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapeutic dogma has been to treat acne scars no less than 6 months after isotretinoin (ITN) cessation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and efficacy of fractional radiofrequency (FRF) in patients treated concurrently with ITN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective randomized control 3\u2010arm comparative trial to evaluate the treatment of acne scars. Patients received one of three treatment options: (A) ITN and FRF concurrent treatment, (B) ITN monotherapy, and (C) FRF 6 months post\u2010ITN treatment. Patients in the FRF cohorts received three monthly sessions. Patients were followed for adverse effects up to 6\u20139 months post\u2010FRF treatment. Final cosmesis was scored by three independent dermatologists using two scales: the Echelle d'Evaluation Clinique des Cicatrices d'Acne (ECCA) and an internal 5\u2010point investigator's scale, indicating the percentage of improvement. Subjective analyses by patients were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Objective and subjective analyses revealed improvement in the ITN\u2010FRF cohort, which was superior to the delayed FRF cohort and the ITN monotherapy cohort. Specifically, the concurrently treated cohort (ITN\u2010FRF) had a significant reduction in acne scar volume from baseline mean (151.1\u2009\u00b1\u200944.7 to 97.0\u2009\u00b1\u200931.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005), outperforming both the delayed FRF and monotherapy ITN treatment cohorts, respectively (155.4\u2009\u00b1\u200937.8 to 122.0\u2009\u00b1\u200946.2, 144.6\u2009\u00b1\u200982.8 to 132.4\u2009\u00b1\u200962.7). Additionally, the concurrently treated cohort demonstrated improved ECCA scores (36.8\u2009\u00b1\u200915.5), significantly better than the ITN monotherapy cohort (101.5\u2009\u00b1\u200920.1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Limited patient sample size: 38 patients completed the study; mostly Fitzpatrick Type II\u2013III skin; photographic assessments utilized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Per our prospective trial, concurrent treatment of ITN\u2010FRF is superior to delayed FRF treatment 6 months post\u2010ITN cessation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23811","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T03:55:28Z","timestamp":1718769328000},"page":"574-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fractional Radiofrequency and Oral Isotretinoin\u2014A Prospective Randomized Controlled Split\u2010Face Trial Comparing Concurrent Versus Delayed Fractional Radiofrequency Treatment for Acne Scars"],"prefix":"10.1002","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-2895","authenticated-orcid":false,"given":"Elisa S.","family":"Gallo","sequence":"first","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel","family":"Katz","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Artzi","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Sackler School of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13462"},{"issue":"9","key":"e_1_2_9_3_1","first-page":"12","article-title":"Acne Scarring\u2010Pathogenesis, Evaluation, and Treatment Options","volume":"10","author":"Connolly D.","year":"2017","journal-title":"The Journal of Clinical and Aesthetic Dermatology"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"655","article-title":"The Duration of Acne Treatment","volume":"13","author":"Huang K. 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