{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T08:53:59Z","timestamp":1777971239191,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Hirsutism is a widespread condition affecting 5%\u201315% of females. Laser treatment of hirsutism has the best long\u2010term effect. Patients with nonpigmented or nonterminal hairs are not eligible for laser treatment, and the current patient journey needed to establish eligibility for laser hair removal is problematic in many health\u2010care systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we compared the ability to assess eligibility for laser hair removal of health\u2010care professionals and convolutional neural network (CNN)\u2010based models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The CNN ensemble model, synthesized from the outputs of five individual CNN models, reached an eligibility assessment accuracy of 0.52 (95% CI: 0.42\u20130.60) and a <jats:italic>\u03ba<\/jats:italic> of 0.20 (95% CI: 0.13\u20130.27), taking a consensus expert label as reference. For comparison, board\u2010certified dermatologists achieved a mean accuracy of 0.48 (95% CI: 0.44\u20130.52) and a mean <jats:italic>\u03ba<\/jats:italic> of 0.26 (95% CI: 0.22\u20130.31). Intra\u2010rater analysis of board\u2010certified dermatologists yielded <jats:italic>\u03ba<\/jats:italic> in the 0.32 (95% CI: 0.24\u20130.40) and 0.65 (95% CI: 0.56\u20130.74) range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current assessment of eligibility for laser hair removal is challenging. Developing a laser hair removal eligibility assessment tool based on deep learning that performs on a par with trained dermatologists is feasible. Such a model may potentially reduce workload, increase quality and effectiveness, and facilitate equal health\u2010care access. However, to achieve true clinical generalizability, prospective randomized clinical intervention studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23843","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T05:43:53Z","timestamp":1727070233000},"page":"80-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Physician Level Assessment of Hirsute Women and of Their Eligibility for Laser Treatment With Deep Learning"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-7746","authenticated-orcid":false,"given":"Kenneth","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Aarhus Denmark"},{"name":"Department of Dermatology and Venereology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca","family":"Jalaboi","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Computer Science Technical University of Denmark Lyngby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Winther","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Computer Science Technical University of Denmark Lyngby Denmark"},{"name":"Center for Genomic Medicine, Rigshospitalet Copenhagen University Hospital Copenhagen Denmark"},{"name":"Department of Biology, Bioinformatics Centre University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Bredsted","family":"Lomholt","sequence":"additional","affiliation":[{"name":"Clinical Institute Aalborg University Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik F.","family":"Lorentzen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine","family":"H\u00f8gsberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Egekvist","sequence":"additional","affiliation":[{"name":"Hudlaege Henrik Egekvist Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"Hedelund","sequence":"additional","affiliation":[{"name":"Hudlaegeklinikken Hobro Hobro Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine","family":"Bertelsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Aarhus Denmark"},{"name":"Department of Dermatology and Venereology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Aarhus Denmark"},{"name":"Department of Dermatology and Venereology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,22]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"168","article-title":"Hirsutism in Women","volume":"100","author":"Matheson E.","year":"2019","journal-title":"American Family Physician"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr042"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)92789-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2021.0125"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14313"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(93)90056-L"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/07399330902785133"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355356"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/13591053030083004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz256"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000002923"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01327.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12021"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1002a48"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.58518"},{"key":"e_1_2_8_17_1","unstructured":"\u201cLaser Hair Removal Market: Global Industry Analysis and Forecast(2022\u20102029) MMR \u201d Maximizemarketresearch 2023 https:\/\/www.maximizemarketresearch.com\/market-report\/global-laser-hair-removal-market\/98199\/."},{"issue":"43","key":"e_1_2_8_18_1","first-page":"4091","article-title":"[Free Versus Non\u2010Free Treatments With Laser and Intense Pulsed Light in Dermatology: Distinguishing Medical Laser Treatments to be Provided Free of Charge From Cosmetic Self\u2010Payment Treatments]","volume":"167","author":"Haedersdal M.","year":"2005","journal-title":"Ugeskrift for laeger"},{"key":"e_1_2_8_19_1","unstructured":"\u201cGuideline for Medical Necessity Determination for Hair Removal \u201d MassHealth Massachusetts Health Care Reform 2021 www.mass.gov."},{"key":"e_1_2_8_20_1","unstructured":"\u201cLasertherapie: schonende Alternative zu bestimmten Operationen \u201d Krankenkasseninfo.de 2023 https:\/\/www.krankenkasseninfo.de\/ratgeber\/magazin\/00423\/lasertherapie-schonende-alternative-zu-bestimmten-operationen.html."},{"key":"e_1_2_8_21_1","unstructured":"\u201cExcessive Hair Growth (hirsutism) \u201d NHS 2022 https:\/\/www.nhs.uk\/conditions\/hirsutism\/."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.0480"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-11-1440"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90746-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.7.2.120"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0747-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1682500"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18354"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17711"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85489-8"},{"key":"e_1_2_8_31_1","volume-title":"Computer Vision and Pattern Recognition","author":"Wang J.","year":"2017"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01602-2"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001531"},{"key":"e_1_2_8_34_1","volume-title":"Computer Vision and Pattern Recognition","author":"Le M. T. Q. V.","year":"2019"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.574329"},{"key":"e_1_2_8_36_1","unstructured":"D.KingmaandJ.Ba \u201cAdam: A Method for Stochastic Optimization \u201d in3rd International Conference on Learning Representations San Diego(2015) Arxiv."},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1109\/TKDE.2006.17"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.01.003"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.08.022"},{"key":"e_1_2_8_41_1","unstructured":"T.Zhao H.Zhang andJ.Spoelstra \u201cA Computer Vision Application for Assessing Facial Acne Severity From Selfie Images \u201dComputer Vision and Pattern Recognition(2019) Arxiv."},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.35.5.742"}],"container-title":["Lasers in Surgery and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/lsm.23843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:36:40Z","timestamp":1747197400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/lsm.23843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,22]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/lsm.23843"],"URL":"https:\/\/doi.org\/10.1002\/lsm.23843","archive":["Portico"],"relation":{},"ISSN":["0196-8092","1096-9101"],"issn-type":[{"value":"0196-8092","type":"print"},{"value":"1096-9101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,22]]},"assertion":[{"value":"2024-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}