{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:17:04Z","timestamp":1740104224729,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Lasers Surg Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There is insufficient evidence to determine the effectiveness of treating allergic rhinitis with a patch laser affix to the skin as opposed to direct intranasal irradiation of the nasal mucosa. We aimed to evaluate the effect of the microneedle patch laser with multiple wavelengths in an allergic rhinitis (AR) mouse model and its underlying mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The microneedle patch laser was attached to the skin above the mouse's nasal cavity, transmitting light to the nasal mucosa. For 10 days, the microneedle patch laser administered simultaneous exposure to wavelengths of 670, 780, 850, and 910\u2009nm at either 10 or 20\u2009min each day. Multiple allergic parameters were evaluated following the microneedle patch laser treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Microneedle patch laser treatment decreased allergic symptoms and inhibited OVA\u2010specific IgE levels. Additionally, it significantly reduced eosinophil infiltration, epithelial thickness of the nasal mucosa, and IL\u20104 cytokine levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The light emitted by the microneedle patch laser attached to the skin, penetrated effectively to the nasal mucosa within the nasal cavity, suggesting potential for treating allergic rhinitis in mice and could be extended in clinical applications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/lsm.23862","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T06:54:03Z","timestamp":1732085643000},"page":"854-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Therapeutic Potential of Microneedle Patch Laser With Multiple Wavelengths in Allergic Rhinitis: Insights From an Allergic Rhinitis Mouse Model"],"prefix":"10.1002","volume":"56","author":[{"given":"Reiza","family":"Ventura","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine Cheonan Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-797X","authenticated-orcid":false,"given":"Jun\u2010Sang","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine Cheonan Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine Cheonan Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-8646","authenticated-orcid":false,"given":"A. Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine Cheonan Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Hyuck","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine Cheonan Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine Cheonan Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-8720","authenticated-orcid":false,"given":"Shin Hyuk","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine Cheonan Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-399X","authenticated-orcid":false,"given":"Gwanghui","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-364X","authenticated-orcid":false,"given":"Ji\u2010Hun","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Dankook University College of Medicine Cheonan Korea"},{"name":"Beckman Laser Institute Korea Dankook University College of Medicine Cheonan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115569"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2023.100799"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-7-s1-s3"},{"issue":"12","key":"e_1_2_8_5_1","first-page":"1440","article-title":"Treatment of Allergic Rhinitis","volume":"81","author":"Sur D. 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